干燥方法对大黄配方颗粒中蒽醌类成分的影响  

Influences of methods of drying on total anthraquinones in Radix et Rhizoma Rhei Dispensing Granules

作　　者：李敏[1] 李晓芳[1] 李丽霞[2] 张乐[1] 刘渝 陈丹丹[1] 

机构地区：[1]成都中医药大学,四川成都610075 [2]成都中医药大学峨眉学院,四川峨眉614201 [3]四川德仁堂中药饮片有限公司,四川成都610061

出　　处：《中成药》2006年第9期1289-1293,共5页Chinese Traditional Patent Medicine

基　　金：国家科技部863项目(2001BA701A40-5)

摘　　要：目的：比较不同干燥方法对大黄配方颗粒中蒽醌类成分的影响。方法：以总蒽醌含量，芦荟大黄素、大黄酸、大黄素、大黄酚和大黄素甲醚的总量为指标，对不同干燥方法进行考察。结果：喷雾条件为浸膏相对密度为1．06～1．10（60℃）进风温度140～150℃，出风温度85～90℃所得的颗粒外观较好，蒽醌类成分破坏最小。结论：大黄配方颗粒最佳的干燥方法是喷雾干燥。AIM ： To compare the influences of drying methods on Radix et Rhizoma Rhei in Dispensing Granules. METHODS： The vaccum and spray methods were studied by determination of total anthraquinones and the sum of aloe-emodin, rheiM, emodin, chrysophanol and physcion. RESULTS： When in spray drying conditions relative density of extract was 1.06-1.10 （60 ℃） and entering wind temperature was at 140-150 ℃, outlet wind temperature was at 85-90℃. Radix et Rhizoma Rhei dispensing granules appearance was good, the total anthraquinones was destroyed least. CONCLUSION： Spray drying method for dispensinp granules has superiorily ever vaccum one.

关 键 词：大黄 配方颗粒 干燥方法 减压干燥 喷雾干燥 

分 类 号：R927.2[医药卫生—药学]