饮酒与老年性痴呆关系的前瞻性队列研究  

Prospective cohort study of relationship between alcohol consumption and risk of dementia

作　　者：邓娟[1] 周华东[1] 李敬诚[1] 王延江[1] 张猛[1] 高长越[1] 陈曼娥[1] 

机构地区：[1]第三军医大学大坪医院野战外科研究所神经内科,重庆400042

出　　处：《中国现代医学杂志》2006年第17期2578-2580,2585,共4页China Journal of Modern Medicine

基　　金：重庆市科委资助项目(No:200123)

摘　　要：目的探讨饮酒和老年性痴呆的关系。方法对重庆市2632名≥60岁老年人进行2年前瞻性队列研究,受试者分为不饮酒,轻中度饮酒,重度饮酒,用简易智能量表(MMSE)和美国精神障碍诊断与统计手册第三版修订本(DSM-III-R)进行痴呆诊断,随访时间内记录痴呆发生的例数,采用运用Logistic回归方法对饮酒和痴呆的关系进行分析。结果在调整了年龄、性别、教育、血压、吸烟、中风史、MMSE评分等危险因素后,与不饮酒者相比,轻中度饮酒使痴呆的危险度降低(RR=0.52,95%CI=0.32-0.85),与不饮酒者相比,轻中度饮酒者患阿尔茨海默病的相对危险度为0.63(RR=0.63,95%CI=0.55-0.72),其他类型痴呆为0.45(RR=0.45,95%CI=0.12-1.69),血管性痴呆为0.31(RR=0.31,95%CI=0.19-0.51)。与不饮啤酒者相比,轻中度饮啤酒者患痴呆的危险度增高(RR=2.47,95%CI=1.23-4.96);与不饮葡萄酒者相比,轻中度饮葡萄酒者患痴呆的危险度降低(RR=0.68,95%CI=0.50-0.92)。结论轻中度饮酒与痴呆的危险度降低有关。[Objective] To investigate the relationship between alcohol consumption and dementia in eldedy people. [Methods] We did a two-year follow-up study of eldedy people from six communities of Chongqing city. Dementia was detected by MMSE （Mini-Mental State Examination） and DSM-Ⅲ-R （Diagnostic and Statistical Manual of Mental Disorders）. The association of alcohol consumption and dementia was investigated using multiple logistic regression models. [Results] Light-to-moderate drinking was associated with a significandy lower risk of dementia compared with nondrinker（RR=0.52, 95%CI=0.32-0.85）. Compared with nondrinkers, light-to-moderate drinking had an decreased risk of Alzheimer＇s disease （RR=0.63, 95%CI=0.55-0.72）, other dementia （RR=0.45, 95%CI= 0.12-1.69） and vascular dementia （RR=0.31, 95%CI=0.19-0.51）through adjusting age, sex, education, blood pressure, smoking status, history of stroke and MMSE score, light to moderate intake of beer was associated with a significantly higher risk of dementia than nondrinker of beer （RR=2.47, 95%CI=1.23-4.96）. Significantly lower risk of dementia was existed at light to moderate drinker （RR=0.68, 95%CI=0.50-0.92）. [ Conclusions] Light-to-moderate drinking was associated with a significandy lower risk of dementia compared with nondrinker.

关 键 词：饮酒 痴呆 危险因素 

分 类 号：R749.16[医药卫生—神经病学与精神病学]