尖锐湿疣鳞状细胞癌变的临床研究  

A clinical study on the condyloma acuminata canceration to squamous cell carcinoma

作　　者：李志清[1] 杜琼[2] 宋林红[3] 杨映云[1] 赵蓉平[1] 杨州[1] 

机构地区：[1]四川省人民医院激光中心,成都市610072 [2]四川省人民医院临床检验中心 [3]四川省人民医院病理科

出　　处：《皮肤病与性病》2006年第3期2-3,共2页Dermatology and Venereology

基　　金：四川省医学科学院四川省人民医院课题基金资助项目(137)

摘　　要：目的探讨尖锐湿疣鳞状细胞癌变的临床特征。方法回顾性分析27例尖锐湿疣鳞癌变的临床特征,病理改变,病毒基因亚型分布,与同期首诊、单纯性尖锐湿疣相比较。结果尖锐湿疣鳞癌变病程长(平均31m),首诊、单纯性尖锐湿疣病程较短(平均3m);病理切片显示前者核硝酸银染色硝酸银颗粒/核面积比显著大于后者;首诊、单纯性尖锐湿疣感染的HPV基因亚型主要为低危型6/11型,尖锐湿疣鳞癌变感染的HPV基因亚型主要为高危型16/18型。结论尖锐湿疣鳞状细胞癌变在病程,病理,病毒基因亚型上显著区别于首诊、单纯性尖锐湿疣。Objective To study the clinical characteristics of the condyloma acuminatum canceration with squamous cell carcinoma. Methods Clinical characteristic,the methods of AgNORs,distribution of subtypes of HPV were used to study and compare between the common condyloma acuminatum and the condy loma acuminatum canceration to squamous cell carcinoma. Results The first group had longer clinical history, there was significant statistic difference in the ratio of AgNOR granular area/nuclear area, HPV subtypes in common condyloma acuminatum were mainly HPV6/11, There was high positive rates of HPV 16/18 in the condyloma acuminatum with squamous cell carcinoma. Conclusion condyloma acumlnatum with squamous cell carcinoma is a special type of condyloma acuminatum with different morphologicai changes, biological characteristics and etiological basis.

关 键 词：乳头瘤病毒 尖锐湿疣 癌变 鳞状细胞 

分 类 号：R730.261[医药卫生—肿瘤] R752.53[医药卫生—临床医学]