玻璃体腔pegaptanib注射后发生视网膜色素上皮撕裂  

Retinal pigment epithelial tear following intravitreal pegaptanib sodium

作　　者：Dhalla M. S. Blinder K. J. Tewari A. 曹绪胜(译) 

机构地区：[1]Dhalla, Barnes Retina Institute, St Louis, MO, United States [2]不详

出　　处：《世界核心医学期刊文摘（眼科学分册）》2006年第9期16-17,共2页Digest of the World Core Medical Journals:Ophthalmology

摘　　要：PURPOSE:To report two cases of a retinal pigment epithelial tear after intravitreal injection of pegaptanib sodium.To our knowledge,this is the first report of this finding after intraocular antivascular endothelial growth factor therapy.DESIGN:Observational case reports.METHODS:Two patients presented with occult choroidal neovascularization and associated serous pigment epithelial detachment that was a result of agerelated macular degeneration.Both patients were treated with an intravitreal injection of pegaptanib sodium.RESULTS:One patient developed a retinal pigment epithelium tear one week after the intravitreal injection.The second patient developed a retinal pigment epithelium tear eight weeks after treatment.CONCLUSIONS:Although these cases may represent natural history,there should be a high index of suspicion for retinal pigment epithelium tears in patients who report significant visual deterioration after intravitreal injection of pegaptanib sodium.Further studies are needed to determine whether angiographic subtypes of choroidal neovascular membranes are more susceptible to developing retinal pigment epithelium tears after treatmentwith antivascular endothelial growth factor agents.PURPOSE： To report two cases of a retinal pigment epithelial tear after intravitreal injection of pegaptanib sodium. To our knowledge, this is the first report of this finding after intraocular antivascular endothelial growth factor therapy. DESIGN： Observational case reports. METHODS： Two patients presented with occult choroidal neovascularization and associated serous pigment epithelial detachment that was a result of agerelated macular degeneration. Both patients were treated with an intravitreal injection of pegaptanib sodium. RESULTS： One patient developed a retinal pigment epithelium tear one week after the intravitreal injection. The second patient developed a retinal pigment epithelium tear eight weeks after treatment. CONCLUSIONS： Although these cases may represent natural history, there should be a high index of suspicion for retinal pigment epithelium tears in patients who report significant visual deterioration after intravitreal injection of pegaptanib sodium. Further studies are needed to determine whether angiographic subtypes of choroidal neovascular membranes are more susceptible to developing retinal pigment epithelium tears after treatmentwith antivascular endothelial growth factor agents.

关 键 词：色素上皮撕裂 玻璃体腔 视网膜 注射后 隐匿性脉络膜新生血管 抗血管内皮生长因子 老年性黄斑变性 色素上皮脱离 

分 类 号：R774.5[医药卫生—眼科]