钌106板近距离放射治疗有临床表现的血管增生性视网膜肿瘤  

Ruthenium-106 plaque brachytherapy for symptomatic vasoproliferative tumours of the retina

作　　者：Anastassiou G. Bornfeld N. Schueler A. O. 刘瑛(译) 

机构地区：[1]Augenklinik, Universitaetsklinikum Essen, 45122 Essen, Germany [2]不详

出　　处：《世界核心医学期刊文摘（眼科学分册）》2006年第9期33-34,共2页Digest of the World Core Medical Journals:Ophthalmology

摘　　要：Aim:To investigate the safety and efficacy of β ray brachytherapy in treatment of vasoproliferative tumours of the retina(VTR).Methods:35 consecutive patients with symptomatic VTR were treated with a ruthenium-106(106Ru)plaque.Three tumours had been treated previously(two with cryotherapy;one with transpupillary thermotherapy).32 VTR(91.4%)were located in the lower half of the retina and all of them were found between the mid-periphery and the ora serrata.The mean tumour thickness was 2.8 mm.An exudative retinal detachment was present in 25 eyes(71.4%)and in 15 cases(42.9%)hard exudates were found in the macula.The major symptom was loss of vision(77.1%).Results:Brachytherapy was well tolerated by every patient.The mean applied dose was 416 Gy at the sclera and 108 Gy at the tumour apex.In all but four eyes(88.6%),it was possible to control the VTR activity.The median follow up time was 24 months.Three of the above mentioned four eyes with treatment failure had had secondary glaucoma before therapy.There was no case of radiation induced neuropathy or retinopathy.Cataract surgery was necessary for five patients.The development of epiretinal gliosis was the most common event during follow up(n=10,28.6%).The mean visual acuity decreased slightly(0.33 before and 0.29 after brachytherapy).Multivariate analysis showed that the presence of macular pathology before treatment was associated with a 6.1-fold risk of vision of 0.25 or better(p= 0.03).Conclusions:β ray brachytherapy with 1106Ru plaques was able to control the activity of VTR and retain vision.Cases with secondary glaucoma before treatment had a very poor prognosis.Aim： To investigate the safety and efficacy of β ray brachytherapy in treatment of vasoproliferative tumours of the retina （VTR）. Methods： 35 consecutive patients with symptomatic VTR were treated with a ruthenium- 106 （^106Ru） plaque. Three tumours had been treated previously （two with cryotherapy; one with transpupillary thermotherapy）. 32 VTR （91.4%） were located in the lower half of the retina and all of them were found between the mid-periphery and the ora serrata. The mean tumour thickness was 2.8 mm. An exudative retinal detachment was present in 25 eyes （71.4%） and in 15 cases （42. 9% ） hard exudates were found in the macula. The major symptom was loss of vision （77.1%） . Results： Brachytherapy was well tolerated by every patient. The mean applied dose was 416 Gy at the sclera and 108 Gy at the tumour apex. In all but four eyes （88.6%）, it was possible to control the VTR activity. The median follow up time was 24 months. Three of the above mentioned four eyes with treatment failure had had secondary glaucoma before therapy. There was no case of radiation induced neuropathy or retinopathy. Cataract surgery was necessary for five patients. The development of epiretinal gliosis was the most common event during follow up （n = 10, 28.6% ）. The mean visual acuity decreased slightly （0. 33 before and 0. 29 after brachytherapy）. Multivariate analysis showed that the presence of macular pathology before treatment was associated with a 6. 1 - fold risk of vision of 0.25 or better （p= 0.03）. Conclusions： β ray brachytherapy with ^1106Ru plaques was able to control the activity of VTR and retain vision. Cases with secondary glaucoma before treatment had a very poor prognosis.

关 键 词：近距离放射治疗 视网膜肿瘤 增生性 临床表现 血管 渗出性视网膜脱离 继发性青光眼 钌 

分 类 号：R730.55[医药卫生—肿瘤]