中等程度的眼内压改变对青光眼患者的共焦扫描激光断层摄影地形图测量结果的影响  

Effect of moderate intraocular pressure ch-anges on topographic measurements with confocal scanning laser tomography in patients with glaucoma

作　　者：Nicolela M. T. Soares A. S. Carrillo M. M. 王永强(译) 

机构地区：[1]Eye Care Centre, 1278 Tower Rd, Halifax, NS B3H 2Y9, Canada [2]不详

出　　处：《世界核心医学期刊文摘（眼科学分册）》2006年第9期61-62,共2页Digest of the World Core Medical Journals:Ophthalmology

摘　　要：Objective:To evaluate optic disc topography changes after intraocular pressure(IOP)modulation in patients with glaucoma.Methods:Twenty-three patients with glaucoma were studied.Three mean optic disc topography images were obtained with the Heidelberg Retina Tomograph II at baseline and weeks 1,2,4,and 8(visits 1,2,3,4,and 5,respectively).Topical medications were discontinued in the study eye after visit 1 and resumed after visit 4 but maintained in the contralateral control eye.Central corneal thickness was measured at the last visit.Topographic changes were determined by stereometric parameters(rim area and mean cup depth)and at discrete topographic locations using the Topographic Change Analysis program(from the Heidelberg Retina Tomograph II).Results:In the study eyes,IOP increased significantly(5.4 mm Hg at visit 4;P<.001)after withdrawal of topical medications but returned to baseline levels after resuming medications;no statistically significant topographic changes,however,were observed.Moreover,no relationship between change in IOP and stereometric parameters was observed.Central corneal thickness was not associated with changes in optic disc topography induced by IOP modulation.Conclusion:In patients with glaucoma,significant but relatively moderate IOP increases and decreases on the order of 5 mm Hg did not appear to have an effect on optic disc topography.Objective： To evaluate optic disc topography changes after intraocular pressure （IOP） modulation in patients with glaucoma. Methods： Twenty-three patients with glaucoma were studied. Three mean optic disc topography images were obtained with the Heidelberg Retina Tomograph Ⅱ at baseline and weeks 1, 2, 4, and 8 （visits 1, 2, 3, 4, and 5, respectively）. Topical medications were discontinued in the study eye after visit 1 and resumed after visit 4 but maintained in the contralateral control eye. Central corneM thickness was measured at the last visit. Topographic changes were determined by stereometric parameters （rim area and mean cup depth） and at discrete topographic locations using the Topographic Change Analysis program （from the Heidelberg Retina Tomograph Ⅱ） . Results： In the study eyes, IOP increased significantly （5.4 mm Hg at visit 4; P 〈0. 001） after withdrawal of topical medications but returned to baseline levels after resuming medications; no statistically significant topographic changes, however, were observed. Moreover, no relationship between change in IOP and stereometric parameters was observed. Central corneal thickness was not associated with changes in optic disc topography induced by IOP modulation. Conclusion： In patients with glaucoma, significant but relatively moderate IOP increases and decreases on the order of 5 mm Hg did not appear to have an effect on optic disc topography.

关 键 词：青光眼患者 扫描激光断层摄影 地形图 眼内压 测量 视神经乳头 中央角膜厚度 共焦 

分 类 号：R775[医药卫生—眼科]