武汉市603例炎症性肠病并发症的临床调查  

Clinical Survey of Complications of Inflammatory Bowel Disease in Wuhan City,Central China

作　　者：李一[1] 夏冰[1] 姜黎[1] 邓长生[1] 丁一娟[2] 罗和生[2] 任宏宇[3] 侯晓华[3] 侯伟[4] 刘南植[4] 许桦林[5] 李瑾[1] 

机构地区：[1]武汉大学中南医院内科,武汉430071 [2]武汉大学人民医院消化内科,武汉430060 [3]华中科技大学同济医学院附属协和医院消化内科,武汉430022 [4]华中科技大学同济医学院附属同济医院消化内科,武汉430030 [5]广州军区武汉总医院消化内科,武汉430070

出　　处：《武汉大学学报（医学版）》2006年第5期653-656,共4页Medical Journal of Wuhan University

基　　金：国家自然科学基金资助项目(编号:30470783)

摘　　要：目的:分析武汉市炎症性肠病(IBD)并发症的临床特点,探讨其与病变程度、范围及治疗方式的关系。方法:回顾性收集1990-2005年武汉市5家医院经结肠镜及病理诊断为IBD病例共603例,其中溃疡性结肠炎(UC)521例,克罗恩病(CD)82例,分别观察各种并发症的发生频率及并发症与其他因素的关系。UC与CD间的差异及相关分析用χ2检验。结果:521例UC中,并发症34例(6.5%),82例CD中,并发症40例(48.8%)。重度UC和全结肠炎患者中并发症的发生率显著高于非重度和远端结肠炎患者(分别25.8%比3.9%,12.8%比4.9%,P<0.01)。有并发症的CD患者的手术史发生率显著高于无并发症患者(57.5%比14.3%,P<0.01),但CD病变范围与并发症的发生无相关性(P>0.05)。结论:CD并发症的发生率高于UC。UC的并发症与疾病病变程度和范围有关,而CD与手术方式有关。Objective： To investigate complications of inflammatory bowel disease （IBD） in Wuhan city, central China and to analyze the association of complications with severity, extent and therapies of the diseases. Methods： A total of 603 cases of IBD, including 521 ulcerative colitis （UC） and 82 Crohn＇s disease （CD）, were retrospectively collected from five central hospitals in Wuhan city during a period from 1990 to 2005. Frequencies of complications of IBD and the association analysis were comprehensively evaluated. Results： Complications were detected in 34 of 521 cases of UC （6.5%） and 40 of 82 cases of CD （48.8%）. The frequencies of complications in severe UC and extensive colitis were significantly higher than in non-severe UC and distal colitis （25.8% vs 3.9% and 12.8% vs 4.9%, P〈0. 01, respectively）. The higher frequency of surgical history of CD was found in patients with complications than in patients without complications （57.5% vs 14.3%, P〈0.01）, but there was no association between location of the disease and complications of CD. Conclusion： The frequency of complications of CD was higher than in that of UC in Wuhan city of China. The complications of UC were associated with severity and extent of the disease and CD was associated with surgical history rather than location of the disease.

关 键 词：并发症 炎症性肠病 溃疡性结肠炎 克罗恩病 

分 类 号：R574.62[医药卫生—消化系统]