PPARδ的结构及其生物学功能与疾病  

A research on the structure and biological functions of PPARδ and its relationship with diseases

作　　者：陈娜[1] 吴英良[1] 

机构地区：[1]沈阳药科大学药学院药理系,辽宁沈阳110016

出　　处：《中国药理学通报》2006年第9期1035-1038,共4页Chinese Pharmacological Bulletin

摘　　要：PPARδ是过氧化物酶体增殖激活受体PPAR的一个亚型,主要控制脂肪组织和骨骼肌细胞的脂类代谢和能量解偶联,并参与许多疾病的发生和发展过程。PPARδ作为治疗靶标,它的合成激动剂有望开发成为治疗皮肤损伤和代谢综合症的有效药物。PPARδ is one of the three isoforms of peroxisome proliferator-activated receptors （PPARs） which are essential regulators of lipid storage and metabolism. PPARδ primarily stimulats lipid metabolism and energy uncoupling in adipocytes and myocytes as well as involvs in the onset and development of many diseases. As the target of medicines, PPARδ agonists may be powerful drugs for epidermal wound and metabolic syndrome X.

关 键 词：PPARΔ 脂类代谢 能量解偶联 皮肤损伤 代谢综合症 

分 类 号：R-05[医药卫生] R329.24