烟酰水杨酸抗心肌缺血家兔氧自由基和脂质过氧化作用  

Anti-oxygen free radicals and anti-lipoperoxidation of nicotinylsalicylic acid to myocardial ischemic rabbit

作　　者：杨旭辉[1] 马建慧[1] 章乐[1] 李悦山[1] 吴越[1] 

机构地区：[1]石河子大学药物研究中心,新疆石河子832002

出　　处：《中国药理学通报》2006年第9期1058-1061,共4页Chinese Pharmacological Bulletin

基　　金：国家重点科技项目(攻关)计划(No96-901-01-70)

摘　　要：目的研究烟酰水杨酸(nicotinylsalicylicacid,NSA)对家兔缺血/再灌注心肌的保护作用。方法用栓线法结扎家兔冠状动脉左室支造成家兔心肌缺血/再灌注损伤,观察分别预防性给予NSA150mg.kg-1.d-12、3、4wk对缺血/再灌注家兔血浆丙二醛(MDA)、超氧化物歧化酶(SOD)的影响。结果NSA预防性给药可降低心肌缺血再灌注家兔血浆MDA生成量,提高SOD活力,具有明显的抗氧化性。结论NSA对缺血/再灌损伤家兔心肌具有保护作用,此作用可能与抑制心肌脂质过氧化、增强抗氧化能力有关。Aim inylsalicylic acid To study the protective （NSA） on myocardial effect of nicotischemical and reperfusion （I/R） injury in the rabbit heart. Methods The model of ischemical and reperfusion injury was set up by ligating the left anterior descending artery. Rabbits were prophylactic treated with 2, 3 or 4 weeks, and then the content of MDA coronary NSA for and the activity of SOD in serum were determined. Results NSA decreased the content of MDA and increased the activity of SOD in serum. Conclusion NSA may obviously prevent the rabbit I/R injury that may be related to its anti-lipoperoxidation property.

关 键 词：烟酰水杨酸 缺血/再灌注 自由基 

分 类 号：R-332[医药卫生] R322.11