缓激肽介导的阿魏酸钠对离体大鼠心脏药理性预适应保护作用  

Cardioprotective effects of SF pretreatment mediated by bradykinin on isolated rat heart

作　　者：刘季春[1] 高涛[1] 邵立建[2] 何明[2] 

机构地区：[1]南昌大学第一附属医院心胸外科,江西南昌330006 [2]南昌大学医学院药理学教研室,江西南昌330006

出　　处：《中国药理学通报》2006年第9期1100-1103,共4页Chinese Pharmacological Bulletin

基　　金：江西省科技厅;教育厅;卫生厅中医处科研基金联合资助项目(No20031202)

摘　　要：目的探讨阿魏酸钠预处理对离体大鼠心脏缺血/再灌注损伤的保护作用及相关机制。方法56只SD大鼠随机分为7组(n=8)正常对照(Con)组、缺血/再灌注损伤(I/R)组、缺血预适应(IP)组、阿魏酸钠(SF)组、卡托普利(CP)组、SF+CP组、SF+HOE140组。采用离体大鼠心脏Langendorff逆行灌注模型,观察各组缺血/再灌注前后心功能指标、SOD、GSH-Px活性、MDA含量的变化。结果SF、CP或IP预处理与SF+HOE140组、I/R组相比较,可明显改善心功能,心肌酶活力升高,MDA含量降低(P<0.05);但SF组、CP组、SF+CP3组比较,组间差异无显著性(P>0.05)。结论SF的PIP保护机制至少部分由缓激肽介导,SF和CP不宜联合应用于临床心肌保护中。Aim： To study the effect of sodium ferulate （SF） pretreatment on isolated rat hearts and its mechanism. Methods Fifty-six SD rats were divided randomly into seven groups （n = 8）： control group; ischemia-reperfusion group; ischemic preconditioning group; SF pretreated group; captopril （CP） pretreated group; SF ＋ CP pretreated group; SF ＋ HOE140 pretreated group. Isolated rat hearts were perfused in the model of Langendorff. The cardiac function, activities of SOD and GSH-Px, contents of MDA were examined before and after ischemia-reperfusion. Results The cardiac function of SF pretreated group, CP pretreated group, and ischemic preconditioned group improved significantly including obvious increment of LVSP, the activities of myocardium SOD and GSH-Px, decrement of the contents of MDA. There is no significance between SF pretreatment, CP pretreatment, and SF ＋ CP pretreatment（P 〉 0.05）. Conclusions One mechanism of SF pretreatment cardioprotective effect is mediated by bradykinin. The combined use of SF and CP doesn＇t result in significant improvement, and thenefore is not advocated.

关 键 词：阿魏酸钠 卡托普利 缓激肽 大鼠 心脏 缺血预适应 

分 类 号：R-332[医药卫生] R284.2