珠海市城区3～6岁儿童常见血液病发生率的调查  

Prevalence of common hematological disorders in children aged 3～6 years in the urban area of Zhuhai city.

作　　者：崔娓[1] 周玉球[1] 肖奇志[1] 张永良[1] 邓玉华[1] 李文典[1] 

机构地区：[1]珠海市妇幼保健院珠海市医学遗传研究所,广东珠海519001

出　　处：《中国儿童保健杂志》2006年第4期392-394,共3页Chinese Journal of Child Health Care

基　　金：广东省自然科学基金(04101691);广东省医学科研基金(A2003737);珠海市科技计划项目(PC200310072)

摘　　要：[目的]了解珠海市城区3～6岁儿童常见血液病的发生率或基因携带率,为制订相应的预防、干预措施提供依据.[方法]随机从珠海市城区健康检查的4 653名3～6岁儿童中抽取1 396名作为研究对象,对其血样进行系统的血红蛋白（Hb）分析、铁代谢状态评估和珠蛋白基因分型以及6-磷酸-葡萄糖-脱氢酶缺乏症（G6PDD）的筛查.[结果]该市城区3～6岁儿童贫血、铁缺乏（iron deficiency,ID）和G6PDD发生率分别为2.72%、2.44%和3.15%;α-和β-地中海贫血（简称地贫）基因检出率各为8.67%和2.22%.[结论]贫血和ID在珠海市3～6岁儿童中并不多见,但地贫和（6PDD则很常见,即该市儿童中有很高的遗传病基因负荷.[Objective] To investigate the prevalence of common hematological disorders in the children aged 3-6 years in the urban area of Zhuhai city. [Methods] 1 396 children were randomly sampled among 4 653 children aged 3- 6 years in the urban area. Their hematological parameters, iron status, genotypes of globin and glucoe-6-phosphate dehydrogenase（G6PD） activity were analyzed systematically by using established techniques or methods. [Results] The prevalencofanemia, irondeficiency （ID） , G6PDdeficiency （G6PDD） , α-andβ- thalassemiawere2. 72 % , 2.44 % , 3. 15 % , 8.67% and 2.22% ,respectively. [Conclusions] Anemia and ID are rare, but thalassemia and G6PDD are very common in this population, that is to say, there is a heavy genetic burden in the preschool children in the urban area of Zhuhai city.

关 键 词：贫血 铁缺乏 6-磷酸葡萄塘脱氢酶缺乏症 发生率 

分 类 号：R722.1[医药卫生—儿科]