急性脑梗死患者血浆t-PA和PAI的变化及临床意义  

The change of plasma t-PA、PAI in acute cerebral infarction and its clinical significance

作　　者：杨霄鹏[1] 李秋芳[2] 王金兰[1] 娄委宇[1] 

机构地区：[1]郑州大学二附院神经内科,郑州450014 [2]郑州大学护理学院临床教研室,郑州450052

出　　处：《中国实用神经疾病杂志》2006年第6期33-34,共2页Chinese Journal of Practical Nervous Diseases

摘　　要：目的探讨血浆组织型纤溶酶原激活物(t-PA)及其抑制物(PAI-1)在急性脑梗死发病中的意义。方法对60例急性脑梗死患者和30名健康者进行血浆t-PA、PAI-1的检测并进行比较。结果急性脑梗死患者较正常对照组t-PA水平明显降低,PAI-1水平明显升高(P<0.05)。结论急性脑梗死患者纤溶活性明显下降,t-PA及PAI-1参与了脑梗死之病理过程,t-PA及PAI-1抗原含量是反映体内纤溶活性的两个重要指标,可用血浆t-PA、PAI-1的含量作为判断病情的参考指标之一。Objective To assess the clinical significance of plasma t-PA, PAI-1 in acute cerebral infarction . Methods Using ELISA,plasma t-PA,PAI-1 concentrations were measured in 60 acute cerebral infarction patients and 30 healthy people. Results In acute cerebral infarction group,the plasma concentrations of t-PA antigen in patients were lower than those of normal control subjects （P〈0.05） ;the plasma concentrations of PAI-1 antigen were significantly higher（P〈0.05）. Conclusion The plasma t-PA and PAI- 1 might play a role in the pathologic changes of cerebral infarction, t-PA and PAI-1 may be two inportant indexes of reflecting fibrinolyric activity.

关 键 词：脑梗死 T-PA PAI 

分 类 号：R743.3[医药卫生—神经病学与精神病学]