创伤对于甲襞黑素瘤预后的影响  

Concomitant traumas influence prognosis in melanomas of the nail apparatus

作　　者：Bormann G. Marsch W.C. Haerting J. Helmbold P. 李晓莉 

机构地区：[1]Department of Dermatology and Venereology,Martin Luther University Halle- Wittenberg,Ernst- Kromayer- Str. 5/6,D- 06097Halle (Saale),Germany

出　　处：《世界核心医学期刊文摘（皮肤病学分册）》2006年第9期31-32,共2页Digest of the World Core Medical JOurnals:Dermatology

摘　　要：Background: In nail apparatus melanomas (NAM), the role of standard melanoma prognostic factors is under discussion. The prognostic influence of traumas to the clinically apparent tumour has not been sufficiently examined. Objectives: To estimate the influence of traumas against the background of standard prognostic factors on the course of NAM. Methods: In 33 patients (20 women, 13 men, median age 65.0 years) with NAM (median tumour thickness 3.5 mm), we retrospectively examined a detailed history of trauma to the affected extremity at first presentation. Histological or other standard prognostic factors and follow-up were studied prospectively using a standardized protocol. results: Of 33 patients, 21 had suffered injury to the clinically apparent melanoma primary between 4 and 72 months prior to definitive surgical treatment (diagnostic biopsy up to 3 months ahead of excision of the melanoma was not considered). Eight of these patients had undergone inadequate therapy procedures. In Kaplan-Meier analysis, trauma to the clinically apparent tumour and tumour thickness were found to be significant prognostic factors for recurrence-free survival, and trauma to the clinically apparent tumour, Clark level and tumour thickness were significant prognosis predictors for overall survival. In Cox’ s proportional hazards model, trauma to the clinically apparent tumour was found to be a significant and independent risk factor with regard to overall survival (hazard ratio 5.39; P = 0.029). An influence of trauma on the primary pathogenesis of NAM could not be confirmed. Only three patients reported trauma prior to the onset of tumour. Conclusions: From our data, trauma to the clinically apparent tumour might be a considerable risk factor in NAM. The diagnosis of NAM should be considered in lesions of the nail apparatus and further deterioration of the prognosis due to inadequate therapeutic attempts or injury to the NAM should be avoided.Background： In nail apparatus melanomas （NAM）, the role of standard melanoma prognostic factors is under discussion. The prognostic influence of traumas to the clinically apparent tumour has not been sufficiently examined. Objectives： To estimate the influence of traumas against the background of standard prognostic factors on the course of NAM. Methods： In 33 patients （20 women, 13 men, median age 65.0 years） with NAM （median tumour thickness 3.5 nun）, we retrospectively examined a detailed history of trauma to the affected extremity at first presentation. Histological or other standard prognostic factors and follow-up were studied prospectively using a standardized protocol, results： Of 33 patients, 21 had suffered injury to the clinically apparent melanoma primary between 4 and 72 months prior to definitive surgical treatment （diagnostic biopsy up to 3 months ahead of excision of the melanoma was not considered）. Eight of these patients had undergone inadequate therapy procedures. In Kaplan-Meier analysis, trauma to the clinically apparent tumour and tumour thickness were found to be significant prognostic factors for recurrence-free survival, and trauma to the clinically apparent tumour, Clark level and turnout thickness were sig- nificant prognosis predictors for overall survival. In Cox＇s proportional hazards model, trauma to the clinically ap- parent tumour was found to be a significant and independent risk factor with regard to overall survival （hazard ratio 5.39; P = 0. 029） . An influence of trauma on the primary pathogenesis of NAM could not be confirmed. Only three patients reported trauma prior to the onset of tumour. Conclusions： From our data, trauma to the clinically apparent tumour might be a considerable risk factor in NAM. The diagnosis of NAM should be considered in lesions of the nail apparatus and further deterioration of the prognosis due to inadequate therapeutic attempts or injury to the NAM should be avoided.

关 键 词：预后因子 黑素瘤 创伤 甲襞 肿瘤预后 外科治疗 肿瘤厚度 危险因子 

分 类 号：R737.9[医药卫生—肿瘤]