冷冻油中N,N甲叉双-5-甲基恶唑烷导致的职业性过敏性接触性皮炎  

Occupational allergic contact dermatitis from N,N methylene-bis-5-methyl-oxazolid-ine in coolant oils

作　　者：Madan V. Beck M.H. 张路坤 

机构地区：[1]CDIU, Hope Hospital, Stott lane, Manchester,M6 8HD, United Kingdom

出　　处：《世界核心医学期刊文摘（皮肤病学分册）》2006年第9期45-46,共2页Digest of the World Core Medical JOurnals:Dermatology

摘　　要：Contact with metal working fluids (MWF) is an important factor in the development of occupational hand dermatitis in patients working in the metal processing industry. Biocides are added to MWF as preservatives and are known sensitizers. We analysed 318 patch test reactions to N,N-methylene-bis-5-methyl-oxazolidine 1% in petrolatum (5-methyloxazolidine, Grotan OX , CAS no. 66204- 44- 2, a formaldehyde releasing biocide) present in coolant oils in patients exposed to MWF and with suspected occupational dermatitis (OD). Positive allergic reactions were noted in 15 (4.7% ) cases. In 7 (47% ) cases, we were able to confirm relevance by examining the material safety data sheets and these showed that N,N-methylene-bis-5-methyloxazolidine was present in the oils used by the patients. No certain relevance could be proved in 8 cases, but in these instances, further information on the biocides used in the oils could not be obtained. Positive reactions to formaldehyde were seen in 11 (73% ) patients. Sensitization either to this biocide and/or formaldehyde allergy was considered to have been likely to have made a contribution to the workers’ dermatitis.Contact with metal working fluids （MWF） is an important factor in the development of occupational hand dermatitis in patients working in the metal processing industry. Biocides are added to MWF as preservatives and are known sensitizers. We analysed 318 patch test reactions to N, N-methylene-bis-5-methyl-oxazolidine 1% in petrolatum （5-methyloxazolidine, Grotan OX, CAS no. 66204- 44-2, a formaldehyde releasing biocide） present in coolant oils in patients exposed to MWF and with suspected occupational dermatitis （OD） . Positive allergic reactions were noted in 15 （4.7%） cases. In 7 （47%） cases, we were able to confirm relevance by examining the material safety data sheets and these showed that N, N-methylene-bis-5-methyloxazolidine was present in the oils used by the patients. No certain relevance could be proved in 8 cases, but in these instances, further information on the biocides used in the oils could not be obtained. Positive reactions to formaldehyde were seen in 11 （73%） patients. Sensitization either to this biocide and/or formaldehyde allergy was considered to have been likely to have made a contribution to the workers＇ dermatitis.

关 键 词：过敏性接触性皮炎 职业性皮炎 恶唑烷 甲叉 冷冻 过敏反应 阳性反应 手部皮炎 

分 类 号：R758.22[医药卫生—皮肤病学与性病学]