GC/MS同时测定尿中吗啡和可待因含量  

Determination of Morphine and Codeine in Urine by GC/MS

作　　者：吴敏[1,2] 王丽[1,2] 张勤[1,2] 

机构地区：[1]浙江医科大学药学系 [2]浙江医科大学中心实验室

出　　处：《现代应用药学》1996年第5期52-54,共3页

摘　　要：建立了ＧＣ／ＭＳ同时测定尿中吗啡和可待因含量的分析方法。线性范围为２０—１０００ｎｇ／ｍｌ（ｒ＝０．９９９７）；方法回收率是：吗啡８６．８±７．９％，可待因８４．７±７．０％。天内测定ＲＳＤ＜１０％，天间测定ＲＳＤ＜１５％。该法已用于生物样品中吗啡和可待因的测定。The analytical method has been developed to assay morphine and codeine in humanurine by Gas Chromatography/Mass Spectrometry. The linear range of the method was 20--1000ng/ml and the mean recoveries are 86. 8 ± 7. 9% (n = 6) for morphine, 84. 7 1 ±7. 0% (n = 6 ) for codeine.The relative standard deviation of intra and inter assay was less than 10% and 15% respectively.The method had been used to assay morphine and codeine in human urine and other biologicalsamples.

关 键 词：尿液 吗啡 可待因 含量 GC MS 

分 类 号：R991[医药卫生—毒理学] R446.12[医药卫生—药学]