MK-801对反复性脑缺血海马神经元损伤的保护作用  

Protective Effects of MK-801 on Hippocampal Neuron Injury Following Repeated Cerebral Ischemia in Rats

作　　者：曹仁存[1] 周厚永[1] 冉春梅[1] 

机构地区：[1]成都军区总医院,成都610083

出　　处：《西南军医》2006年第5期1-3,共3页Journal of Military Surgeon in Southwest China

摘　　要：目的研究反复性脑缺血海马神经元的病理损害及其机制。方法应用45Ca放射自显影及光镜对比观察大鼠单次性和反复性脑缺血及NMDA受体拮抗剂MK-801治疗后海马钙积聚和神经元损害的病理改变。结果反复缺血组海马异常钙积聚与迟发性神经元损害(DND)明显重于单次缺血组;MK-801显著减轻海马钙积聚与组织病理损害。结论兴奋毒机制在反复性脑缺血海马神经元损伤中起着重要作用。Objective To study the neuronal pathological damage and its mechanism of hippocampus following repeated cerebral ischemia. Methods ^45Ca autoradiography and light microscopy were used to observe the calcium accumulation and neuronal pathological changes of hippocampus following repeated cerebral ischemla in the rats in comparison with the damage following single cerebral ischemia. The effects of MK-801, a NMDA receptor antagonist, were also examined. Results The abnormal calcium accumulation and delayed neuronal death （DND） were found to be more severe in the hippocampus in the group of repeated cerebral ischemia than those in the single ischemia insult group. MK-801 was effective in reducing or ameliorating the calcium accumulation and hlstopathological damage in the hippocampus. Conclusions These findings indicate that excitotoxic mechanism plays a major role in hoppocampal neuron injury following repeated cerebral ischemia.

关 键 词：脑缺血 反复缺血 海马 放射自显影 兴奋性氨基酸(EAA) 

分 类 号：R743[医药卫生—神经病学与精神病学]