Alzheimer病与轻度认知功能障碍的脑SPECT显像  

Brain SPECT imaging of Alzheimer's disease and mild cognitive impairment

作　　者：高平[1] 秦绍森[1] 蔡晓杰[1] 刘银红[1] 韩丽君[2] 于治国[2] 

机构地区：[1]卫生部北京医院神经内科,100730 [2]卫生部北京医院核医学科,100730

出　　处：《中华核医学杂志》2006年第4期213-215,共3页Chinese Journal of Nuclear Medicine

摘　　要：目的探讨脑 SPECT 显像对阿尔茨海默病(AD)和轻度认知功能障碍(MCI)的早期诊断及预后判定价值。方法对33例 AD、17例 MCI 患者和12例认知正常者进行 SPECT 检查及随访研究。结果 AD 组典型表现是双侧颞顶叶低灌注,在颞叶、顶叶、额叶、丘脑和扣带回血流灌注均明显低于 MCI 和认知正常组(P<0.05);MCI 组仅在颞叶血流灌注明显低于认知正常组(P<0.05)。不稳定型 MCI 组扣带回血流灌注明显低于稳定型 MCI 组(P<0.05)。结论 SPECT 显像可为早期诊断 AD 和 MCI 提供客观评定脑功能的指标,对 MCI 预后判定有重要价值。Objective To assess the early diagnostic and prognostic value of brain SPECT imaging in Alzheimer＇s disease （AD） and mild cognitive impairment （MCI）.Methods Brain SPECT imaging and follow-up study were performed in 33 AD patients,17 MCI patients and 12 cognitive normal subiects.Results The typical feature of AD was bilateral temporoparietal bypoperlusion.Compared with MCI and normal group,the regional cerebral blood flow （rCBF） of temporal lobe,parietal lobe,frontal lobe,thalamus and cingulum decreased significantly （P〈0.05）.MEI had a significant lower rCBF in temporal lobe only than that in normal group （P〈0.05）.Besides,the rCBF in eingulum of instable MCI was much lower than that in cinguloum of stable MCI（P〈0.05）.Conclusion Brain SPECT imaging can provide useful information for the early diagnosis of AD and MCI,and also for the prognosis of MCI.

关 键 词：阿尔茨海默病 认知障碍 体层摄影术 发射型计算机 单光子 ECD 

分 类 号：R749.1[医药卫生—神经病学与精神病学]