口腔鳞癌的^(18)F-FDG PET/CT的影像学表现以及与CT平扫的比较研究  

Oral Cavity Squamous Cell Carcinomas:A Comparative Study on ^(18)F-FDG PET/CT Appearances and Plain CT Scan

作　　者：王欣璐[1] 王全师[1] 吴湖炳[1] 王明芳[1] 王巧愚[1] 李洪生[1] 张雪林[2] 

机构地区：[1]南方医科大学附属南方医院PET中心,广东广州510515 [2]南方医科大学附属南方医院影像中心,广东广州510515

出　　处：《实用放射学杂志》2006年第8期995-998,共4页Journal of Practical Radiology

基　　金：2003年度国家自然科学基金资助(No:30370426);2003年度广东省科技计划项目资助(No:2003C32729);2005年度国家自然科学基金资助(No:30500136)

摘　　要：目的评价18F-FDG PET-CT检查在口腔鳞癌患者的诊断和淋巴结转移灶发现的价值。方法回顾性地分析了18例口腔癌(其中包括16例舌癌和2例口底癌患者)的临床和18F-FDG PET-CT影像学表现及CT平扫的影像学资料。结果(1)原发病灶的发现:全部病例中有5例患者是由PET/CT检查首次发现口腔癌的;PET/CT对原发部位肿瘤病变显示的灵敏度100%(15/15),特异性100%(3/3);CT对原发病灶显示的灵敏度为73.3%(11/15),特异性为66.7%(2/3)。(2)18例口腔癌患者中PET/CT诊断颈部淋巴结转移灶共26个,大小介于0.8~1.5cm之间,标准摄取值(SUV)介于2.5~3.2之间;其中仅有5个淋巴结经病理组织活检证实为淋巴结转移灶。(3)通过PET/CT检查新发现全身其他部位的侵犯和远处转移性病灶8个。结论PET/CT对口腔鳞癌原发灶诊断的灵敏度和特异性均比CT平扫高;全身PET/CT扫描对舌癌和口底癌的临床分期、术后复发的判定更具价值。Objective To investigate the value of PET/CT in diagnosis of the primary tumor of oral cavity squamous cell carcinomas and in detection of lymph node metastasis. Methods PET/CT and CT plain scan data of oral cavity squamous cell carcinomas in 18 cases （ 16 tongue cancer and 2 mouth floor cancer） proved by pathology were retrospectively analysed. Results （ 1 ） In the discovery of the primary tumor ：the sensitivity and specificity were 15/15 （ 100% ） and 3/3 （ 100% ） in PET/CT, 11/15 （73.3% ） and 2/3 （ 66.7%） in CT,5 original lesions of oral cavity cancer in all patients were first found by PET/CT ; （2） 26 cervical lymph nodes of metastasis were detected by PET/CT, the size were between 0.8 and 1.5cm,standardized uptake values（ SUV ） were between 2.5 - 3.2. Among them only 5 lymph nodes were confirmed by pathologic biopsy ; （ 3 ） 8 patients with distant metastases and invadation were found by FDG PET/CT. Conclusion Compared with conventional imaging （CT plain scan） , FDG PET/CT proved as sensitive and specific for the detection of primer oral cavity squamous cell carcinomas. PET/CT appeared to be a useful and noninvasively feasible examination method in diagnosis of oral cavity squamous cell carcinomas.

关 键 词：口腔 鳞状细胞癌 正电子发射体层成像 体层摄影术 X线计算机 

分 类 号：R739.8[医药卫生—肿瘤] R814.42[医药卫生—临床医学]