高原地区Hp相关性胃癌前病变患者血清6种细胞因子水平的变化  

Changes of Serum Level of Th1/Th2 Cellular factors and Helicobacter Pylori (Hp)-induced Gastric Carcinoma

作　　者：杜娟[1] 杨永耿[1] 熊元治[1] 周翠萍[1] 李英存[1] 杨桂英[1] 

机构地区：[1]青海省人民医院消化科,810007

出　　处：《高原医学杂志》2006年第3期13-16,共4页Journal of High Altitude Medicine

摘　　要：目的:观察青海高原地区幽门螺杆菌(Hp)相关性胃癌前病变患者血清Th1/Th2细胞因子(IL-1β、IL-2、IL-4、IL-6、IL-8、TNF)水平变化,以探讨其在发病中的可能免疫致病机制。方法:应用放免法(RIA)测定25例慢性萎缩性胃炎(CAG)、17例肠化生(IM)、15例异型增生(Dys)患者血清IL-1β、IL-2、IL-4、IL-6、IL-8、TNF的含量。比较Hp感染与非感染胃癌前病变患者之间;Hp感染CAG炎症活动与非活动患者之间;Hp感染CAG、IM、Dys患者之间血清6种细胞因子含量的差别。结果:Hp感染与非感染胃癌前病变患者之间6种细胞因子含量均无显著性差别(P>0.05);Hp感染CAG炎症活动者血清IL-4含量显著低于非活动者(P<0.05);IM和Dys者均非常显著低于CAG(P<0.01),IL-2在Dys组显著高于CAG(P<0.05)。结论:本地区Hp相关性胃癌前病变中存在血清Th1/Th2失衡,表现为随着胃癌前病变的逐级加重,T淋巴细胞高表达IL-2伴随IL-4低表达现象。Objective： To observe the relationship between serum level of Th1/Th2 cellular factors （IL-- 1β,IL--2,IL--4,IL--6 ,IL--8 ,TNF ）and Hp--induced gastric carcinoma at high altitude. Methods： 25 cases with chronic atrophic gastritis （CAG）, 17 intestinal metaplasia （IM） and 15 cases with Dys were enrolled in our study. The serum level of IL--1β,IL--2,IL--4,IL--6 ,IL--8 ,TNF were measured by RIA and compared with the non--infective HP control group. Results： No difference in cellular factors was found between Hp infective and non--Hp infective group （P〉0.05）, but level of IL--4 in patients with active Hp--induced CAG was lower than that in rest cases （P〈0.05）. The level of IL--2 was significant higher in AH group than that in CAS group （P〈0.05）. Conclusions： There is a abnormal changes in Th1/ Th2, in which the level of IL--2 increases with the development of gastric carcinoma, but level of IL--4 decreases at high altitude.

关 键 词：高原 幽门螺杆菌 胃癌前疾病 细胞因子 血清 

分 类 号：R735.2[医药卫生—肿瘤] R446.113[医药卫生—临床医学]