2,6-二卤苯胺合成方法的改进  

IMPROVEMENT OF THE SYNTHESIS OF 2,6-DIHALOANILINES

作　　者：李兴[1] 张星[1] 杜秀芳[1] 聂辉[1] 

机构地区：[1]河北医科大学药学院药物化学教研室,河北石家庄050017

出　　处：《河北医科大学学报》2006年第5期365-366,共2页Journal of Hebei Medical University

摘　　要：目的尝试用过硼酸钠替代过氧化氢合成2,6-二卤苯胺。方法对氨基苯磺酰胺与卤化氢在过硼酸钠存在下进行反应,制备3,5-二卤-4-氨基苯磺酰胺,再经水解得2,6-二卤苯胺。结果成功地合成了目标化合物。结论此改进可以准确控制投料量,提高最终产物的纯度,收率亦佳。Objective To explore synthesizing method of 2, 6-dihaloanilines by using sodium perborate as oxidizing agent instead of hydrogen perhydroxide. Methods 4- Aminobenzenesulfonamide reacted with hydrogen halide in the presence of sodium perborate to give 3, 5-dihalo-4-aminobenzenesulfonamides which underwent hydrolysis to produce 2, 6- dihaloanilines. Results 2, 6-Dihaloanilines were synthesized successfully. Conclusion The result showed that it was easy to control the reagent amount and the purity and yield of 2, 6- dihaloanilines were good enough by this method.

关 键 词：2 6-二氯苯胺 2 6-二溴苯胺 过硼酸钠 合成 

分 类 号：R914.5[医药卫生—药物化学]