TGF-β_1在前列腺癌中的表达及其与生存率关系的研究  

The expression of TGF-β_1 in prostate cancerand its relation withsurvival rate of patients

作　　者：丁国芳[1] 徐银峰[1] 杨最素[1] 郁迪[1] 闫海强[1] 

机构地区：[1]浙江海洋学院医学院人体解剖与组织胚胎学教研室,舟山316004

出　　处：《浙江医学》2006年第9期709-711,共3页Zhejiang Medical Journal

基　　金：浙江省自然科学基金资助项目(Y205519);浙江海洋学院科研基金资助项目(X05LY13)

摘　　要：目的探讨转化生长因子-β1(TGF-β1)在前列腺癌组织中的表达及其与术后生存率的关系,阐明TGF-β1在前列腺癌临床进展中的作用和作为预后指标价值。方法用EnVisionTM免疫组织化学法,检测41例前列腺癌切除标本中癌组织和10例癌周组织TGF-β1的表达;结合临床资料分析TGF-β1与前列腺癌术后生存率的关系。结果前列腺癌中TGF-β1阳性表达率87.81%,与癌周组织(20.00%)比较,差异有统计学意义(P<0.01)。术后生存2年以内者的TGF-β1阳性表达率100%,2～5年者88.27%,5年以上者72.58%,它们间的差异有统计学意义(P<0.05)。TGF-β1表达呈中、强阳性者38.46%(10B26)术后生存5年以上,表达阴性或弱阳性者80.00%(12B15)术后生存5年以上,两者的差异有统计学意义(P<0.05)。TNM分期Ⅰ、Ⅱ期者TGF-β1阳性表达率为70.83%(17B24例),Ⅲ、Ⅳ期者为100%(17例),两者间的差异有统计学意义(P<0.05)。无骨转移者TGF-β1阳性表达率为83.87%(26/31),有骨转移者为100%(10/10),两者间的差异有统计学意义(P<0.05)。结论TGF-β1表达率越高,肿瘤发展越快,转移性越强,患者生存率越低。TGF-β1可促进前列腺癌生长,增加前列腺癌的侵袭能力。对患者行TGF-β1检测,可判断前列腺癌的进展和预后。Objective To investigate the expression of TGF-β1 in prostate cancer tissues and its relation to survival rate of patients. Methods The expression of TGF-β1 was detected by immunohistochemical method in 41 specimens of prostate tissue and 10 specimens of normal tissue,The survival rate of patientsafter operation was investigated. Results The positive expression rate of TGF-β1 in prostate cancer was 87.81%（36/41）, while it was 20.00% （2/10） in controls （P〈0,01）. The positive expression of TGF-β1 in those who died in 2 years after operation was 100%, while in those who died in 2-5 year was 88.27%, and in those who died after 5 years was 72,58%（P〈0.05）. The intermediate and strong positive expression of TGF-β1 in those who died after 5 years was 38.46% （10/26）.. The negative and lower positive expression of TGF-β1 in those who died after 5 years was 80.00%（12/15）. The positive expression of TGF-β1 inprostate cancer TNMⅠ, Ⅱ was 70.83%（17/24） and that was 100%（17/17） in TNM Ⅲ,Ⅳ（P〈0.05 ）. The positive expression of TGF-β1 in those who had no bone metastasis was 83.87%, while it was 100% in those who had bone metastasis （P〈0.05）. Conclusion The higher TGF-β1 values might be associated with the worse prognosis and rapid progressionof prostate cancer.

关 键 词：前列腺癌 TGF—β1 生存率 

分 类 号：R737.25[医药卫生—肿瘤]