Syntheses and Biological Activities of Novel Benzotriazole Compounds Containing a Thioamide Group  

作　　者：XU Liang-zhong ZHAI Zhi-wei YU Guan-ping QIN Yong-qi YANG Ya-xun 

机构地区：[1]College of Chemistry and Molecular Engineering, Qingdao University of Science and Technology, Qingdao 266042, P. R. China

出　　处：《Chemical Research in Chinese Universities》2006年第5期574-576,共3页高等学校化学研究（英文版）

摘　　要：（E） -2- （ 1H-Benzo [ d ] [ 1,2,3 ] trlazol-1-yl） -3- （4-chlorophenyl） -3 -hydroxy-N-phenylprop-2 -enethioamide （ compound 1 ） and （E） -2- （ 1H-benzo [ d ] [ 1,2,3 ] trlazol-1-yl ） -3 -hydroxy-N, 3 -diphenylprop-2-enethioamide （ compound 2） were synthesized and their structures were confirmed by means of IR, MS, ^1H NMR, and elemental analysis. The structure of compound 1 was determined with single-crystal X-ray diffraction analysis. The results of the biological test show that the two compounds have a certain antifungal activity.（E） -2- （ 1H-Benzo [ d ] [ 1,2,3 ] trlazol-1-yl） -3- （4-chlorophenyl） -3 -hydroxy-N-phenylprop-2 -enethioamide （ compound 1 ） and （E） -2- （ 1H-benzo [ d ] [ 1,2,3 ] trlazol-1-yl ） -3 -hydroxy-N, 3 -diphenylprop-2-enethioamide （ compound 2） were synthesized and their structures were confirmed by means of IR, MS, ^1H NMR, and elemental analysis. The structure of compound 1 was determined with single-crystal X-ray diffraction analysis. The results of the biological test show that the two compounds have a certain antifungal activity.

关 键 词：BENZOTRIAZOLE THIOAMIDE Crystal structure Biological activities 

分 类 号：O626.26[理学—有机化学]