Synthesis and Characterization of Novel Acetohydroxyacid Synthase Inhibitors  

作　　者：GAO Fei-fei LI Yao-xian ZHANG Suo-qin ZHANG Guang-liang 

机构地区：[1]College of Chemistry, Jilin University, Changchun 130021, P. R. China

出　　处：《Chemical Research in Chinese Universities》2006年第5期593-597,共5页高等学校化学研究（英文版）

摘　　要：A novel kind of acetohydroxyacid synthase（AHAS） inhibitors, arylsulfonylaminocarbonyl-2-thiohydantoins, was synthesized based on biorational design. The structures of these compounds were confirmed by IR, MS, NMR, and elemental analysis. The results of the preliminary activity tests indicate that most of the arylsulfonylamidecarbonyl-5- methyl-2-thiohydantoins have a higher biological activity than those without 5-methyl substituent.A novel kind of acetohydroxyacid synthase（AHAS） inhibitors, arylsulfonylaminocarbonyl-2-thiohydantoins, was synthesized based on biorational design. The structures of these compounds were confirmed by IR, MS, NMR, and elemental analysis. The results of the preliminary activity tests indicate that most of the arylsulfonylamidecarbonyl-5- methyl-2-thiohydantoins have a higher biological activity than those without 5-methyl substituent.

关 键 词：Sulfonylaminocarbonyl-2-thiohydantoin SULFONYLUREA Acetohydroxyacid synthase  Herbicidal activity 

分 类 号：TQ457.2[化学工程—农药化工]