SULFONYLUREA

作品数：43被引量：93H指数：5
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相关作者：陈海峰董喜成陈敏伯张涛更多>>
相关机构：中国农业大学中国科学院更多>>
相关期刊：《World Journal of Clinical Cases》《Journal of US-China Medical Science》《Journal of Integrative Agriculture》《Chinese Journal of Structural Chemistry》更多>>
相关基金：国家自然科学基金国家重点基础研究发展计划国家科技支撑计划天津市自然科学基金更多>>
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Transient diabetes mellitus with ABCC8 variant successfully treated with sulfonylurea:Two case reports and review of literature
《World Journal of Diabetes》2024年第8期1811-1819,共9页Ling-Hua Shen Yan Cui Dong-Xia Fu Wei Yang Sheng-Nan Wu Hui-Zhen Wang Hai-Hua Yang Yong-Xing Chen Hai-Yan Wei 
Supported by the Department of Science and Technology of Henan Province,China,No.222102310461。
BACKGROUND Transient neonatal diabetes mellitus(TNDM)is a rare form of diabetes mellitus that usually presents within the first 6 mo of life.Patients often enter remission within several months,although relapse can oc...
关键词：Neonatal diabetes mellitus ABCC8 Sulfonylurea receptors 1 KATP channels SULFONYLUREA GLYBURIDE Insulinulin Case report 
Ion Channel Dysregulation Following Intracerebral Hemorrhage
《Neuroscience Bulletin》2024年第3期401-414,共14页Xiangyu Zhang Yan Zhang Qiuyang Su Yang Liu Zhe Li V.Wee Yong Mengzhou Xue 
supported by the National Natural Science Foundation of China(82071331,81870942,and 81520108011);the National Key Research and Development Program of China(2018YFC1312200);the Canadian Institutes of Health Research(VWY).
Injury to the brain after intracerebral hemorrhage(ICH)results from numerous complex cellular mechanisms.At present,effective therapy for ICH is limited and a better understanding of the mechanisms of brain injury is ...
关键词：Intracerebral hemorrhage Ion dyshomeostasis Sulfonylurea 1 transient receptor potential melastatin 4 TWIK-related K+channel 1 N-methyl-Daspartate receptor Transient receptor potential vanilloid 4 
Generation of sulfonylureas under photoredox catalysis and their biological evaluations
《Chinese Chemical Letters》2022年第11期4860-4864,共5页Xuefeng Wang Jun Zhang Qi Chen Wei Zhou Jie Wu 
Financial support from National Natural Science Foundation of China(No.21871053);the Leading Innovative and Entrepreneur Team Introduction Program of Zhejiang(No.2019R01005);the Open Research Fund of School of Chemistry and Chemical Engineering,Henan Normal University(No.2020ZD04)。
Traditional synthesis of sulfonylureas largely depends on nucleophilic addition of arylsulfonamides to presynthesized isocyanates.Now we report a new access to alkylsulfonylureas with good yields and broad substrate s...
关键词：SULFONYLUREA Chlorosulfonyl isocyanate PHOTOCATALYSIS 
Certain sulfonylurea drugs increase serum free fatty acid in diabetic patients:A systematic review and meta-analysis
《World Journal of Clinical Cases》2022年第26期9524-9535,共12页Ming Yu Xiao-Yu Feng Shuai Yao Chang Wang Ping Yang 
Supported by National Natural Science Foundation of China,No.81570360。
BACKGROUND Sulfonylurea(SU)is a commonly used antidiabetic drugs effective for type 2diabetes mellitus.Previous studies have reported that the SU treatment could alter the serum free fatty acid(FFA)concentration in di...
关键词：SULFONYLUREA Free fatty acid Cardiovascular disease Diabetes mellitus Systematic review META-ANALYSIS 
Related Genes and Treatments of Transient and Permanent Diabetes Mellitus
《Journal of US-China Medical Science》2022年第2期70-76,共7页Xinyu Yu 
NDM(neonatal diabetes mellitus)is a rare genetic disease,which happens in the 6 months of life.Some patients with NDM heal on their own,but the other patients will show the symptoms of NDM for their whole life.Based o...
关键词：NDM genetic mutations INSULIN SULFONYLUREA CRISPR/CAS9 
Bitter gourd extract improves glucose homeostasis and lipid profile via enhancing insulin signaling in the liver and skeletal muscles of diabetic rats
《Asian Pacific Journal of Tropical Biomedicine》2021年第8期344-352,共9页Saber Mohamed Eweda Mennatallah Ahmed Ali Hala Mohamed Abd El-Bary Nahed Hussein El-Sokkary Madiha Hassan Helmy Maher Abdel-Nabi Kamel 
Objective:To investigate the modulatory effects of bitter gourd extract on the insulin signaling pathway in the liver and skeletal muscle tissues of diabetic rats.Methods:The ethanolic extract of bitter gourd was prep...
关键词：NEONATAL STREPTOZOTOCIN Diabetic SULFONYLUREA Bitter gourd Phosphorylated insulin receptor Protein kinase C IRS-1 GLUT2/GLUT4 Insulin signaling 
Inhibition Performance of Some Sulfonylurea on Copper Corrosion in Nitric Acid Solution Evaluated Theoretically by DFT Calculations
《Open Journal of Physical Chemistry》2020年第3期139-157,共19页Mougo André Tigori Amadou Kouyaté Victorien Kouakou Paulin Marius Niamien Albert Trokourey 
The theoretical study of chlorpropamide, tolazamide and glipizide was carried out by the Density Functional Theory (DFT) at B3LYP/6-3...
关键词：CHLORPROPAMIDE Tolazamide GLIPIZIDE Density Functional Theory Copper Corrosion 
Precise base editing of non-allelic acetolactate synthase genes confers sulfonylurea herbicide resistance in maize被引量：9
《The Crop Journal》2020年第3期449-456,共8页Yanmin Li Jinjie Zhu Hao Wu Changlin Liu Changling Huang Jinhao Lan Yanming Zhao Chuanxiao Xie 
supported by the Key Area Research and Development Program of Guangdong Province(2018B020202008);the National Natural Science Foundation of China(31771808);Beijing Municipal Science and Technology Project(D171100007717001);the National Key Research and Development Program of China(2016YFD0101803);National Engineering Laboratory for Crop Molecular Breeding。
Single-nucleotide polymorphisms contribute to phenotypic diversity in maize. Creation and functional annotation of point mutations has been limited by the low efficiency of conventional methods based on random mutatio...
关键词：Precise base editing of non-allelic acetolactate synthase genes confers sulfonylurea herbicide resistance in maize 
Design, synthesis and SAR study of novel sulfonylurea derivatives containing arylpyrimidine moieties as potential anti-phytopathogenic fungal agents被引量：1
《Chinese Chemical Letters》2019年第12期2160-2162,共3页Wei Chen Yuxin Li Yunyun Zhou Yi Ma Zhengming Li 
supported by the National Natural Science Foundation of China(Nos.21702173,21502229);Fundamental Research Funds for the Central Universities(No.2682016CX104);Miaozi Project of Scientific and Technological Innovation of Sichuan Province(No.2018090)
Acetohydroxyacid synthase(AHAS) was considered as a promising target for antifungal agents.Herein,three series of novel sulfonylureas(SUs) 9-11 containing aromatic-substituted pyrimidines were designed and synthesized...
关键词：SULFONYLUREA Phytopathogenic fungi Antifungal activity Substituted pyrimidine 3D-QASR 
Increased risk for cerebral ischemic stroke in diabetes: genetically polymorphic CYP mediated production of neuroprotective EETs and sulfonylurea metabolism in relation with KATP channels
《Acta Pharmacologica Sinica》2019年第4期569-570,共2页Umit Yasar Melih 0. Babaoglu 
Dear Editor, Szeto et al. thoroughly reviewed the role of ATP sensitive potassium (KATP) channels in cerebral ischemic stroke and diabetes in a recent article [1]. KAtp channels are expressed in many organs, such as b...
关键词：INCREASED RISK CEREBRAL ischemic stroke KATP channels 
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