Ion Channel Dysregulation Following Intracerebral Hemorrhage  

作　　者：Xiangyu Zhang Yan Zhang Qiuyang Su Yang Liu Zhe Li V.Wee Yong Mengzhou Xue 

机构地区：[1]Department of Cerebrovascular Diseases,The Second Afliated Hospital of Zhengzhou University,Zhengzhou 450000,China [2]Academy of Medical Science,Zhengzhou University,Zhengzhou 450000,China [3]Hotchkiss Brain Institute and Department of Clinical Neurosciences,University of Calgary,Calgary,AB T2N 1N4,Canada

出　　处：《Neuroscience Bulletin》2024年第3期401-414,共14页神经科学通报（英文版）

基　　金：supported by the National Natural Science Foundation of China(82071331,81870942,and 81520108011);the National Key Research and Development Program of China(2018YFC1312200);the Canadian Institutes of Health Research(VWY).

摘　　要：Injury to the brain after intracerebral hemorrhage(ICH)results from numerous complex cellular mechanisms.At present,effective therapy for ICH is limited and a better understanding of the mechanisms of brain injury is necessary to improve prognosis.There is increasing evidence that ion channel dysregulation occurs at multiple stages in primary and secondary brain injury following ICH.Ion channels such as TWIK-related K+channel 1,sulfonylurea 1 transient receptor potential melastatin 4 and glutamate-gated channels affect ion homeostasis in ICH.They in turn participate in the formation of brain edema,disruption of the blood-brain barrier,and the generation of neurotoxicity.In this review,we summarize the interaction between ions and ion channels,the effects of ion channel dysregulation,and we discuss some therapeutics based on ion-channel modulation following ICH.

关 键 词：Intracerebral hemorrhage Ion dyshomeostasis Sulfonylurea 1 transient receptor potential melastatin 4 TWIK-related K+channel 1 N-methyl-Daspartate receptor Transient receptor potential vanilloid 4 

分 类 号：R743.34[医药卫生—神经病学与精神病学]