Generation of sulfonylureas under photoredox catalysis and their biological evaluations  

作　　者：Xuefeng Wang Jun Zhang Qi Chen Wei Zhou Jie Wu 

机构地区：[1]Taizhou Central Hospital(Taizhou University Hospital)&School of Pharmaceutical and Materials Engineering,Taizhou University,Taizhou 318000,China [2]Department of Chemistry,Fudan University,Shanghai 200438,China [3]State Key Laboratory of Organometallic Chemistry,Shanghai Institute of Organic Chemistry,Chinese Academy of Sciences,Shanghai 200032,China [4]School of Chemistry and Chemical Engineering,Henan Normal University,Xinxiang 453007,China

出　　处：《Chinese Chemical Letters》2022年第11期4860-4864,共5页中国化学快报（英文版）

基　　金：Financial support from National Natural Science Foundation of China(No.21871053);the Leading Innovative and Entrepreneur Team Introduction Program of Zhejiang(No.2019R01005);the Open Research Fund of School of Chemistry and Chemical Engineering,Henan Normal University(No.2020ZD04)。

摘　　要：Traditional synthesis of sulfonylureas largely depends on nucleophilic addition of arylsulfonamides to presynthesized isocyanates.Now we report a new access to alkylsulfonylureas with good yields and broad substrate scope.With the insertion of commercialized chlorosulfonyl isocyanate under photoredox catalysis,alkylsulfonylureas are synthesized in one-pot from the corresponding anilines and silyl enolates.A reaction mechanism is proposed showing the transformation undergoes a radical process,and the practicality of this methodology is proven via application to bioactive molecules.Additionally,the anti-cancer and anti-virus screening of these compounds is evaluated.

关 键 词：SULFONYLUREA Chlorosulfonyl isocyanate PHOTOCATALYSIS 

分 类 号：O622.6[理学—有机化学] O643.36[理学—化学] O644.1