草酸铂或顺铂联合氟脲嘧啶及醛氢叶酸治疗晚期胃癌的对比研究  

Comparative Study on Patients with Advanced Gastric Cancer Treated with Oxaliplatin or Cisplatin Combining with 5-Fluorouracil and Leucovorin

作　　者：谢忠[1] 谢杰荣[1] 温继育[1] 冯丽萍[1] 

机构地区：[1]广东医学院附属医院肿瘤内科,广东省湛江市524001

出　　处：《中国肿瘤临床》2006年第18期1041-1043,1046,共4页Chinese Journal of Clinical Oncology

摘　　要：目的:比较L-OHP+CF+5-FU方案与DDP+CF+5-FU方案对初次化疗的Ⅲ期胃癌患者的疗效、不良反应及生活质量的改善情况。方法:A组(34例)接受L-OHP+CF+5-FU方案治疗;B组(36例)接受DDP+CF+5-FU方案治疗。两组均以3周为1周期,重复3个周期。客观疗效与不良反应按WHO标准进行评价,生活质量根据临床受益疗效评价。结果:A、B两组客观疗效(CR+PR)分别为52.9%及50.0%,P>0.05;白细胞减少及恶心呕吐反应B组均较A组明显(P<0.01);外周神经炎A组比B组明显(P<0.05),但较轻微,均在Ⅰ～Ⅱ度范围内。两组均未发现其他严重的不良反应。临床受益疗效A组高于B组(P<0.05)。结论:L-OHP+CF+5-FU方案与DDP+CF+5-FU方案治疗晚期胃癌的客观疗效无明显差异性,但前者耐受性好,患者生活质量改善明显。Objective： To compare the effect, toxicity and quality of life （QQL） between Oxaliplatin plus leucovorin and 5-Fluorouracil （L-OHP＋CF＋5Fu）regimen and Cisplatin plus Leucovorin and 5-Fluorouracil （DDP＋CF＋5Fu）regimen in primary patients with advanced Gastric Cancer （stage Ⅳ）. Methods： Group A （34 cases）were treated with L-OHP＋CF＋5Fu regimen and group B（36 cases）were treated with DDP＋CF＋5-Fu regimen. Both regimens were repeated every 3 weeks for three cycles. Objective tumor response and cytotoxic reactions were assessed by WHO criteria. QOL was evaluated by clinical benefit response. Results： The objective response rate （CR＋PR）was 52.9% in group A compared to 50.0% in group B （P〉0.05）. Leukopenia, nausea and vomiting in group B were more serious than those in group A（P〈0.01）. Peripheral neuritis had higher incidence in group A （P〈0.05）, but that was slight （within Ⅰ and Ⅱ degree）. No other serious adverse reactions occurred in either group. Clinial benefit response in group A was higher than that in group B （P〈0.05）. Conclusion The present study indicated that L-OHP＋CF＋5-Fu regimen had lower toxicity, longer median survival time and better QOL than DDP＋CF＋5-Fu regimen for advanced Gastric cancer, however there was no significant statistical difference in the obiective response rate between the two groups.

关 键 词：胃癌 草酸铂 醛氢叶酸5-氟脲嘧啶 顺铂 

分 类 号：R735.2[医药卫生—肿瘤]