肺癌患者血清细胞生长因子及受体联合检测的临床意义  

Clinical Significance of Detecting Serum Vascular Endothelial Growth Factor、Epidermal Growth Factor Receptor And Platelet Derived Growth Factor in Patients with Lung Cancer

作　　者：周静敏[1] 马淑萍[1] 秦建文[1] 史东升[1] 刘昌起[1] 

机构地区：[1]天津市胸科医院胸内科,天津市300052

出　　处：《中国肿瘤临床》2006年第18期1055-1057,1060,共4页Chinese Journal of Clinical Oncology

摘　　要：目的:探讨联合检测血管内皮生长因子(VEGF)、表皮生长因子受体(EGFR)、血小板衍生生长因子(PDGF)对肺癌的诊断价值和靶向治疗的监测作用。方法:采用双抗体夹心ABC-ELISA法测定肺癌患者及健康对照组血清血管内皮生长因子、表皮生长因子受体、肺癌患者血小板衍生生长因子。结果:肺癌组血清VEGF、EGFR、PDGF测定值均高于正常对照组(P<0.001)。联合检测VEGF+PDGF+EGFR对肺癌诊断的敏感性91.4%、特异性53.3%、准确性73.8%。。血清VEGF、PDGF、EGFR值与非小细胞肺癌分期有关,与肺癌病理分型无关(P>0.05)。血清VEGF与PDGF及EGFR测定值之间呈正相关。在接受重组血管内皮抑素治疗的患者中,三项指标有下降的趋势。结论:VEGF、EGFR、PDGF的联合检测对肺癌诊断具有一定临床指导意义。对肺癌的靶向治疗可能有监测作用。Objective： To explore the diagnosis and target therapy effect of the serum VEGF, EGFR and PDGF in patients with lung cancer. Methods： The sandwich enzyme-linked immunoabsorbent assay （ELISA） was used to detect serum VEGF ,EGFR and PDGF in patients with lung cancer and 40 normal healthy controls. Results： Compared with healthy control group, the level of serum VEGF ,EGFR and PDGF in lung cancer group were much higher （P〈0.001）. The serum VEGF ,PDGF and EGFR level were correlated with TNM stage in NSCLC. There were no relationship between the serum VEGF,EGFR,PDGF level and lung cancer pathological style （P〉0.05）. The serum VEGF level was positively correlated with EGFR and PDGF. Conclusion： The combined detection of the serum VEGF,PDGF and EGFR have very important directive significance in estimating lung cancer diagnosis and target therapy.

关 键 词：血管内皮生长因子 表皮生长因子受体 血小板衍生生长因子 肺癌 分期 

分 类 号：R734.2[医药卫生—肿瘤]