G72基因与抑郁症的关联研究  

Association between depression and G72 gene polymorphism

作　　者：洪武[1] 方贻儒[1] 汪作为[1] 钱依萍[2] 张钦廷[3] 江三多上海市精神卫生中心 王祖承[1] 

机构地区：[1]上海交通大学医学院精神医学教研室,上海市精神卫生中心200030 [2]上海市精神卫生中心 [3]司法部司法鉴定科学技术研究所

出　　处：《中华医学遗传学杂志》2006年第5期532-535,共4页Chinese Journal of Medical Genetics

基　　金：国家自然科学基金(30270494)~~

摘　　要：目的探讨抑郁症与G72基因多态性的关系,以及是否有混合家族史的抑郁症其G72基因多态性有无区别。方法应用聚合酶链反应技术分别检测符合《中国精神障碍分类与诊断标准》的100例无混合家族史抑郁症、50例有混合家族史抑郁症、86名正常对照的G72基因的单核苷酸多态性rs947267、rs2181953 ,并进行关联分析。结果 (1)女性无混合家族史抑郁症组与对照组rs947267基因型及等位基因分布频率,差异均有统计学意义(P=0 .017、P=0 .008) ,基因型A/A、等位基因A、C的OR值分别为0 .300(P=0 .010)、0 .456(P=0 .008)、2 .195(P=0 .008) ,而男性差异均无统计学意义(P>0 .05) ;(2)不同性别无混合家族史抑郁症组与对照组rs2181953基因型及等位基因分布,差异均无统计学意义(P>0 .05) ;(3)不同性别有混合家族史抑郁症组与对照组rs947267、rs2181953基因型及等位基因分布,差异均无统计学意义(P>0·05)。结论 G72基因多态性可能与女性无混合家族史的抑郁症患者存在关联,其中rs947267的C等位基因是危险因子。Objective To investigate the association between G72 gene polymorphisms and depression, and to probe the difference of G72 gene polymorphisms between depression with and without mixed family history. Methods The polymorphisms of G72 gene （rs947267 and rs2181953） were detected by PCR technique in 100 depressive patients without mixed family history, 50 depressive patients with mixed family history and 86 normal controls. Results （ 1 ） The frequencies of rs9d-7267 genotypes and alleles in female depressive patients without mixed family history were significant different to the controls （ P = 0.017 and P = 0.008）, the OR scores were 0.300 （A/A, P = 0.010）, 0.456（A, P = 0.008） and 2. 195（C, P = 0.008） respectively; but in male patients there were no significant differences to the controls P 〉 0.05）. （2） The frequencies of rs2181953 genotypes and alleles in the depressive patients without mixed family history were not significantly different to the controls regardless of sex （ P 〉 0.05）. （3） The frequencies of rs947267 and rs2181953 genotypes and alleles in the depressive patients with mixed family history were not significantly different to the controls regardless of sex （ P 〉 0.05）. Conclusion The G72 gene polymorphism may be associated with female depressive patients without mixed family history, C allele of rs9d-7267 may be the risk factor.

关 键 词：抑郁症 混合家族史 G72基因 

分 类 号：R749.4[医药卫生—神经病学与精神病学]