血小板糖蛋白GPIb α Kozak基因多态性与短暂性脑缺血发作的相关性研究  

Correlation between the polymorphism of platelet glycoprotein GPIb α Kozak gene and transcient ischemic attack

作　　者：宋玉强[1] 邹宏丽[2] 张晨[1] 

机构地区：[1]青岛大学医学院附属医院神经内科,266003 [2]青岛大学医学院第二附属医院

出　　处：《中华医学遗传学杂志》2006年第5期561-564,共4页Chinese Journal of Medical Genetics

摘　　要：目的研究青岛地区汉族人群血小板糖蛋白(platelet glycoprotein,GP) GPIbαKozak序列-5T/C基因多态性与短暂性脑缺血发作(transient ischemic attack,TIA)的关系。方法应用序列特异性引物PCR扩增和基因序列测定技术检测90例TIA患者和80名对照组的GPIbαKozak序列-5T/C基因多态性,比较各基因型的表达与TIA的关系。结果 TIA组CC基因型频率为0 .166 ,明显高于对照组(0 .075) ,两组差异有统计学意义(P<0 .05) ,TIA组C等位基因与对照组比较显著增高(P<0 .05)。Logistic回归分析结果显示C等位基因与TIA发病正相关(P=0 .016)。结论血小板GPIbαKozak基因多态性与TIA相关,CC基因型和C等位基因可能是TIA的危险因素。Objective Genic susceptibility could increase the risk of transcient ischemic attack （TIA）. The objective of this study is to investigate the relationship between the polymorphism of platelet glycoprotein GPIb α Kozak gene and TIA in Qindao Han population. Methods The polymorphisms of platelet glycoprotein GPIb α Kozak gene - 5T/C in TIA patients and normal control were detected with sequence-specific primers polymerase chain reaction （PCR-SSP）. Results The prevalence of the CC genotype and C alleles were significantly higher in TIA patients than in the control group （P 〈 0.05）. The positive correlation between C allele and TIA was showed by Logistic regression analysis （P = 0.016）. Conclusion The - 5T/C polymorphism of the platelet glycoprotein GPIb α Kozak gene is implicated in the pathogenesis of TIA. C allele is an independent risk factor for TIA.

关 键 词：短暂性脑缺血发作 血小板糖蛋白 遗传多态性 

分 类 号：R743[医药卫生—神经病学与精神病学]