人类视网膜神经节细胞的凋亡  

Apoptosis in Human Retinal Ganglion Cell

作　　者：徐格致[1,2] 李维英[1,2] 曹安民[1,2] 

机构地区：[1]上海医科大学附属眼耳鼻喉科医院 [2]香港中文大学眼科和视觉科学系

出　　处：《眼科研究》1996年第3期193-194,共2页Chinese Ophthalmic Research

摘　　要：为了解凋亡在脉络膜黑色素瘤引起的视网膜变性中所起的作用，８例脉络膜黑色素瘤并发各种视网膜病变的眼球被选作病理组织学和ＴＤＴｍｅｄｉａｔｅｄｂｉｏｔｉｎ－ｄＵＴＰｎｉｃｋ－ｅｎｄｌａｂｅｌｉｎｇ（ＴＵＮＥＬ）技术研究。其中４眼观察到凋亡的特征性改变—视网膜神经节细胞和内颗粒层细胞核的ＤＮＡ片断化。结果表明凋亡是脉络膜黑色素瘤并发视网膜病变中神经节细胞和内颗粒层细胞的死亡方式之一。urpose:To examine the role of apoptosis in retinal degenerative process in maligant melanoma of choroid.Method:8 human eyes with various retinal degeneration secondary to maligant melanoma of choroid were studied by histopathology and TDT mediated biotin dUTP nick end labelling technique.Result:The characteristic DNA fragmentation of apoptosis was observed in scattered ganglion cells and cells of inner nuclei layer in 4 of 8 eyes.Conclusion:The results suggested that apoptosis is one of the pathways of ganglion cells and cells of inner nuclei layer death in retinal degeneration secondary to maligant melanoma of choroid.

关 键 词：细胞凋亡 视网膜 神经节细胞 黑色素瘤 

分 类 号：R739.72[医药卫生—肿瘤]