慢性缺氧大鼠膈肌线粒体形态计量研究  

Changes of mitochondrial volume density of the diaphragm in response to chronic hypoxia in rats

作　　者：王东林[1] 毛宝龄[1] 钱桂生[1] 郭先健[1] 李淑平[1] 张新立[2] 

机构地区：[1]第三军医大学附属新桥医院呼吸内科研究所 [2]第三军医大学基础部病理学教研室

出　　处：《第三军医大学学报》1996年第5期390-391,共2页Journal of Third Military Medical University

基　　金：国家自然科学基金

摘　　要：通过慢性常压和减压间断缺氧模型，用计算机图像分析系统对大鼠膈肌线粒体形态学指标进行了立体计量。结果：各缺氧组膈肌线粒体体密度显著增加，其它形态学参数变化不大。提示慢性缺氧大鼠膈肌线粒体主要是数量和体积等量的变化。The changes of the mitochondrial morphological parameters of the diaphragm in response to chronic hypoxia were observed in rats. It was found that after exposure to hypobaric hypoxia or normobaric hypoxia 8 h per day for one or three months, the mitochondrial volume density of the diaphragm was significantly increased by 9.5%～19.1% ( P <0.05～0.01) while other parameters were not significantly changed. The findings suggest that the aerobic oxidative capacity of the diaphragm could be partly improved through an increase of the mitochondrial volume density.

关 键 词：缺氧 膈肌 线粒体 

分 类 号：R364.4[医药卫生—病理学]