2-硫代-4-喹唑啉二酮类化合物的合成研究  

Synthesis of 2-tioxoquinazolin-4-ones

作　　者：彭红丹[1] 杨建宏[1] 杨桂春[1] 陈祖兴[1] 

机构地区：[1]湖北大学化学与材料科学学院,湖北武汉430062

出　　处：《湖北大学学报（自然科学版）》2006年第3期282-284,292,共4页Journal of Hubei University：Natural Science

基　　金：国家自然科学基金(20372019)

摘　　要：研究了合成2-硫代-4-喹唑啉二酮的合成方法,该方法应用膦亚胺与CS2的氮杂Wittig反应,得到异硫氰酸苯酯,再与伯胺平行反应,一次性合成了10种喹唑啉二酮衍生物,产率在61.55%～87.58%,其结构由IR,^1HNMR,^13C所确证.Twelve 2- thioquinazolin- 4- ones were rapidly synthesized by a new parallel synthetic method, which included aza - Wittig reaction of iminophosphorane with carbon disulfide to give phenyl isothiocyanate and subsequent reaction of isothiocyanate with various amines in a parallel fashion. The structure of compound 2 - thioquinazolin - 4 - ones was confirmed by means of ^1HNMR, ^13C and IR.

关 键 词：2-硫代喹唑啉-4-酮 氮杂WITTIG反应 平行合成 

分 类 号：O625.7[理学—有机化学]