人白血病细胞受RA、TPA诱导分化过程中其细胞蛋白质的变化  

The Relevant Changes of Cellular Proteins in Human Leukemic Cells During the Process of Differentia During the Process of Differentia

作　　者：李群[1] 陈子兴[1] 陈悦书[1] 

机构地区：[1]苏州医学院附属第一医院江苏省血液研究所

出　　处：《苏州医学院学报》1996年第4期616-617,共2页Acta Academiae Medicinae Suzhou

摘　　要：３５例各型白血病患者骨髓原代细胞，作ＲＡ、ＴＰＡ诱导分化前后细胞蛋白质ＳＤＳ－ＰＡＧＥ分析，结果发现，除了少数几种蛋白质外，白血病细胞蛋白质的成分和含量在１４．８５～１８１．２ｋｕ分子量范围内存在不均一变化。对１例Ｍ４型白血病细胞诱导分化前后的微量蛋白质双向电泳分析，发现这些蛋白质的变化都偏于ｐＨ的酸性侧。he SDS-PAGE analyse on cellular proteins of primarily cultured bone marrow cells induced byRA or TPA from 35 patients with variety of leukemia revealed that the component and quantity ofcellulal proteins over a range from 14.85～181. 2ku of molecular weight had inconstant changesduring the induced differentiation, while some protein changes could be repeatedly found in several cas cases of the same type of leukemia. The protein changes of one case of M4 leukemic cells induced by RAor TPA visualized by 2D microelectrophs and silverstaining were found on the acidic side of PAG

关 键 词：白血病细胞 维甲维 咐拜醇酯 细胞蛋白质 

分 类 号：R733.702[医药卫生—肿瘤]