各种动员剂方案在恶性淋巴瘤自身外周血造血干细胞移植中的应用及其临床效果观察  

USING THREE KINDS OF MOBILIZED AGENT SCHENE IN MALIGNANT LYMPHOMA COMBINED AUTOLOGOUS PERIPHERAL STEM CELL TRANSPLANTATION AND CLINICAL EFFECTIVE OBSERVATION

作　　者：俞受程[1] 张伟京[1] 邓春江[1] 阎安文 马恩普 刘淑珍 苏航[1] 鲍云华[1] 

机构地区：[1]解放军第307医院肿瘤科

出　　处：《上海医学》1996年第10期590-594,共5页Shanghai Medical Journal

摘　　要：对３组共２０例恶性淋巴瘤病人进行自身外周血干细胞回输，采用三种不同的动员剂和治疗方案：１．皮质激素动员；口服强的松或静注地塞米松可使收集浓聚的白细胞明显增多，为给药前自身血的４．ｂｌ倍和７．２４倍。２．硫酸葡聚糖（ＤＳ）动员：１０％葡萄糖液９～１０ｍｌ＋Ｎ，Ｓ．１００ｍｌ静滴，在外周血干细胞高峰期进行分离，其ＷＢＣ，ＭＮＣ和ＣＦＵ－ＧＭ分别为使用前的２．０４倍、４．１４倍和２．０４倍。３．Ｇ－ＣＳＦ或ＣＴＸ＋Ｇ－ＣＳＦ动员：平均分离２．６次总数可获得ＷＢＣ１５．４７×ｌ０￣９、ＭＮＣ１３．８９×ｌ０￣９、ＣＦＵ－ＧＭ２５．４×ｌ０￣５、１３．２４×ｌ０￣７。临床应用：１．激素动员组化疗采用ＣＴＸ＋ＶＣＲ，分别输入２，１１×１０￣９和２．４０×ｌ０￣９，其中ＣＦＵ－Ｃ产率为０．７２×ｌ０￣５和０．３３×ｌ０￣５，可以加速造血恢复。２．ＤＳ动员组化疗采用ＣＨＶＰ方案，输入自身干细胞ＭＮＣ５．５×ｌ０￣９、ＣＦＵ－ＧＭ１．５４×ｌ０￣５。输后１４天白细胞（ＷＢＣ）恢复至４×ｌ０￣９／Ｌ以上，ＰＴ在输后１６天恢复至照前水平。３．Ｇ－ＣＳＦ或ＣＴＸ＋Ｇ－ＣＳＦ动员组化疗采用ＣＨＶＰ方案或超大剂量化疗（ＢＣＮＵ＋ＶＰ－?0 cases malignant lymphoma were divided into three groups which patients reinfusedautologous peripheral stem cells and adopted three kinds of mobilized agent and chemo-thera-peutic scheme,1.Hormone Group:Using pred.or dexamethasone,WBC was increased significantly. It was 4. 6l and 7.24 fold compared with pre-mobilization,After chemotherapy(CTX+VCR),MNC(2.11×109and2.40×109)andCFU-GM(0.7×105 nd 0.33×105)wasreinfused.It hastened hemopoietic reconstitution,2.Dextron sulfate(DS)Group:10%DS9～10ml+N.S. 100ml I.V.The WBC,MNC and CFU-GM was 2.04,4.14 and 2.04 fold respectively compared with pre-mobilization. After chemotherapy(CHVP),the total MNC(5.5 × 109)and CFU-GM(1.54 × l05) was refused.WBC recovered more than 4× l09/L in14 days,while Pt was in l6 days at normal level.3.G-CSF or CTX+G-CSF Group:Afterhigh dose chemotherapy or super high dose chemotherapy(CHVP or BCNU + Vp-l6 +CTX),thetotal WBC(15.47×109),MNC(13.89×109),CFU-GM(25.4×105),cells(13.24× 107)was reinfused.WBC recovered more than 2.2×109/L in l6 days,wmkPt was50×109/L in l9 days. It was an ideal stem cell mobilized agent and satisfactory effect for tu-mour remission.

关 键 词：淋巴肉瘤 造血干细胞移植 自体移植 

分 类 号：R733.405[医药卫生—肿瘤]