利培酮对首发精神分裂症患者整夜睡眠脑电活动的影响  

Effects of risperidone on polysomnography in patients with first-episode schizophrenia

作　　者：陈兴时[1] 张明岛[1] 楼翡璎[1] 王红星[2] 王继军 梁建华[1] 陈冲[1] 陈欣伟 刘丽[5] 高存友[6] 刘萍[7] 刘效巍[8] 

机构地区：[1]200030上海市精神卫生研究所神经生理室 [2]公安部北京安康医院脑电生理室 [3]日本琉球大学医学院医学研究科 [4]杨森制药有限公司上海办事处 [5]中国医科大学心理卫生医院脑电生理室 [6]中国人民解放军第160医院脑电生理室 [7]天津市安定医院功能科 [8]大连医科大学附一院神经内科

出　　处：《中华医学杂志》2006年第35期2467-2470,共4页National Medical Journal of China

基　　金：国家自然科学基金(30470626);上海市科学技术委员会科技攻关项目(054119534)

摘　　要：目的应用多导睡眠图(PSG)探讨利培酮对首发精神分裂症患者睡眠脑电活动的影响。方法 25例患者连续进行4夜 PSG 描记,其中第3、4晚睡前予1.2 mg 利培酮,观察用药后 PSG的变化。结果患者组服用利培酮后夜间睡眠总时间增加(基线睡眠值378 min±30 min,第3晚服药后406 min±34 min,第4晚服药后427 min±31 min,F=34.762,P<0.01),睡眠效率提高(基线睡眠值86%±10%,第3晚服药后90%±10%,第4晚服药后93%±12%,F=3.215,P<0.05),觉醒时间减少(基线睡眠值34 min±17 min,第3晚服药后23 min±15 min,第4晚服药后19 min±8 min,F=7.459,P<0.01),S_1阶段减少(基线睡眠值22%±10%,第3晚服药后15%±9%,第4晚服药后18%±9%,F=4.12,P<0.05),S2阶段增加(基线睡眠值54%±16%,第3晚服药后56%±18%,第4晚服药后65%±11%,F=3.484,P<0.05)。而睡眠潜伏期和慢波睡眠(SWS)尚未见明显变化。结论利培酮能改善睡眠质量。Objective To investigate the effects of risperidone on the polysomnography （PSG） in the patients with first-episode schizophrenia. Methods Twenty-five patients with first-episode schizophrenia, 13 males and 12 females, aged 29 ± 8, underwent polysomnographic recording for 4 consecutive nights, the first night being used for acclimatization, and on the 3 rd and 4 th nights risperidone in the dose of 1.2 mg was administered before going to bed. Forty-four healthy persons, 23 males and 21 females, aged 28 ± 8, underwent polysomnographic recording for 2 consecutive nights, the first night being used for acclimatization. Results The baseline PSG recording showed that in comparison with the normal control group the total sleep time of the schizophrenia patients was shorter （ 378 min ± 30 min vs 462 min ± 21 min）, sleep latency was longer （30 min ± 14 min vs 18 min ±8 min）, rapid eye movement （REM） sleep latency was shorter （59 min ±20 min vs 88 min ± 10 min）, REM sleep time was shorter （61 min ± 17 min vs 84 min ± 12 min）, awakening time was longer （ 34 min ± 17 min vs 15 min ± 5 min）, stage 1 （ S1 ） time was longer （22% ± 10% vs 9. 0% ± 1.7% ）, S3 time and S4 time were shorter, and the sleep efficacy was lower （ 86% ± 10% ） （ P 〈 0. 05 - P 〈 0. 01 ） ; however, there was no significant difference in the S2 time between these 2 groups （ 54% ± 16% vs 56% ± 4% , P 〉 0. 05 ）. In the schizophrenia group, in comparison with the baseline levels in the third and fourth nights the total sleep times were significantly increased （406 min ± 34 min and 428 min ± 31 min respectively）, the awakening times were significantly decreased （23 min ± 15 min and 19 min ± 8 min respectively）, and S1 times were significantly decreased （14 min ±9 min and 10 min ±9 min respectively）, with such changes time-dependently; and in the 4 th night the REM sleep time was significantly increased （87 min ± 20 min ） and the sleep efficacy was significantly improve

关 键 词：精神分裂症 多道睡眠描记术 抗精神病药 

分 类 号：R749.3[医药卫生—神经病学与精神病学]