SERUM CONCENTRATIONS OF HYALURONIC ACID, PROCOLLAGEN TYPE III NH_2-TERMINAL PEPTIDE, AND LAMININ IN PATIENTS WITH CHRONIC CONGESTIVE HEART FAILURE  

作　　者：Gang Li Qing-bo Yan Liang-ming Wei 

机构地区：[1]Division of Cardiology, Department of Geriatrics, the First Affiliated Hospital, Chongqing University of Medical Sciences, Chongqing 400016 [2]Department of Nuclear Medicine, the Second Affiliated Hospital, Chongqing University of Medical Sciences, Chongqing 400010

出　　处：《Chinese Medical Sciences Journal》2006年第3期175-178,共4页中国医学科学杂志（英文版）

摘　　要：Objective To explore the role of serum fibrotic indices including hyaluronic acid （HA）, procollagen type Ⅲ NH2-terminal peptide （PCIIIP）, and laminin （LN） in assessing the severity of myocardial fibrosis in chronic congestive heart failure （CHF）. Methods Serum levels of HA, PCIIIP, and LN in 39 patients with CHF E [14 with New York Heart Association （NYHA） functional class II, 21 with class Ⅲ, 4 with class Ⅳ] and in 46 patients with NYHA functional class I were assessed by radioimmunoassay. Results The serum concentrations of HA, PCMP, and LN were 359.75 ± 84.59 μg/L, 77.88 ± 24. 67 μg/L, 86. 73 ± 23.90 μg/L in CHF group, and 211.60 ±54. 80 μg/L, 64.82 ±23.99 μg/L, 82. 26 ±23.98 μg/L in NYHA functional class Ⅰ group, respectively. The HA level was significantly higher in CHF patients as compared with NYHA functional class Ⅰ group （ P 〈 0.05 ）. However, no difference was found in the levels of PCIIIP and LN between CHF group and NYHA functional class Ⅰ group. The serum HA concentration was negatively correlated with left ventricular ejection fraction （ r = - 0.71, P 〈 0.05 ）. Conclusion Serum HA level may act as an indicator for myocardial fibrosis.

关 键 词：congestive heart failure hyaluronic acid procollagen type Ⅲ NH2-terminal peptide LAMININ 

分 类 号：R541.6[医药卫生—心血管疾病]