β-catenin的表达与胃癌临床病理特征的关系  

Relationships between Expressions of β-catenin and the Clinicopathological Features in Human Gastric Cancers

作　　者：靳文剑[1] 陈火国[1] 钟礼瀑[1] 汪凌玲[1] 张焜和[2] 

机构地区：[1]江西省肿瘤医院,330029 [2]南昌大学医学院一附院消化科,330006

出　　处：《实用癌症杂志》2006年第4期360-362,370,共4页The Practical Journal of Cancer

基　　金：江西省卫生厅资助项目(0303070)

摘　　要：目的探讨胃癌组织中β-catenin的表达与胃癌临床病理特征的关系。方法应用EnVision法检测60例早期胃癌、60例进展期胃癌组织中β-catenin表达情况,并比较β-catenin在不同临床病理特征的胃癌组织中的表达差异。结果早期胃癌组织中β-catenin阳性表达率为63.3%,不同组织学类型(肠型和弥漫型)、不同分化程度(高、中、低)、有无淋巴结转移的早期胃癌,其组织中β-catenin阳性表达率相互比较,均存在显著性差异(P<0.05),但与浸润深度无显著性相关(P>0.05)。进展期胃癌组织中β-catenin的阳性表达率为55.0%,不同分化程度及有无淋巴结转移的进展期胃癌,其组织中β-catenin的阳性表达率相互比较存在非常显著性差异(P<0.01),但与组织学类型、腹膜转移及远处转移无显著性相关(P>0.05)。结论β-catenin表达减低与胃癌的发生、发展有关。Objective To investigate the relationships between expressions of β-catenin and clinicopathological features in human gastric cancers. Methods The immunohistochemical staining of β-catenin was performed using EnVision method in 120 specimens ： 60 from patients with early gastric cancer and 60 from patients with advanced gastric cancer. Results The positive rate of β- catenin expression in early gastric cancer was 63.3%, with significant differences between two types （intestinal and diffuse） gastric cancer, with or without lymph node metastasis and among different differentiation types（P 〈 0.05）,but without significant differences between different depths of invasion （P 〉0.05）. In the advanced gastric cancer, the positive rate of β-catenin expression was 55.0%, with significant differences between different differentiation types and with or without lymph node metastasis（P〈0.01）, but not between different histological types, with and without peritoneal spreading and distant metastasis （P 〉0.05）. Conclusion The reduced expression of β-catenin is correlated with the development and progression of gastric cancer.

关 键 词：胃癌 Β-连环素 免疫组织化学 临床病理特征 

分 类 号：R735.2[医药卫生—肿瘤]