胃排空的测定:^(13)C-辛酸呼气试验与闪烁显像的比较  

Measuring gastric emptying:Comparison of ^(13)C-octanoic acid breath test and scintigraphy

作　　者：Punkkinen J. Konkka I. Punkkinen O. 张红凯 

机构地区：[1]Department of Medicine,Porvoo Hospital,P.O.Box 500,06151 Porvoo,Finland Dr.

出　　处：《世界核心医学期刊文摘（胃肠病学分册）》2006年第9期9-10,共2页Core Journals in Gastroenterology

摘　　要：The aim of this study was to compare scintigraphy,the standard method,and the 13C-octanoic acid breath test(OBT)for measuring gastric emptying.Patients with functional dyspepsia(N = 21,8 men and 13 women;ages,40-75)underwent standardized dynamic scintigraphy and OBT.Scintigraphic images were obtained for 90 min and breath samples for 4 hr.The gastric half-emptying time for solids(T1/2)was calculated by two previously described mathematical models for the OBT samples:the nonlinear least-squares method and the geometrical method.T1/2 was significantly longer measured by OBT than by scintigraphy(167±50 min for the nonlinear least-squares method(P < 0.05)and 185±52 min for the geometrical method(P < 0.005)vs.109 ±74 min for scintigraphy).No correlation appeared between T1/2 measured by scintigraphy and T1/2 measured by OBT(r = 0.26)for nonlinear least-squares method and(r =-0.13)for geometrical method).Furthermore,the correlation between the two mathematical models appeared to be low(r = 0.15).Although OBT is simple and safe,its correlation with scintigraphy appears to be weak.The usefulness of this test for measuring gastric emptying thus requires further validation.The aim of this study was to compare scintigraphy, the standard method, and the ^13C-octanoic acid breath test （OBT） for measuring gastric emptying. Patients with functional dyspepsia （N = 21, 8 men and 13 women; ages, 40- 75） underwent standardized dynamic scintigraphy and OBT. Scintigraphic images were obtained for 90 rain and breath samples for 4 hr. The gastric half-emptying time for solids （T1/2） was calculated by two previously described mathematical models for the OBT samples： the nonlinear least-squares method and the geometrical method. T1/2 was significantly longer measured by OBT than by scintigraphy （167 ± 50 min for the nonlinear least-squares method （P 〈 0.05） and 185 ±52 rain for the geometrical method （P 〈 0.005） vs. 109 ＋ 74 rain for scintigraphy）. No correlation appeared between T1/2 measured by scintigraphy and T1/2 measured by OBT （r = 0.26） for nonlinear least-squares method and （r = -0. 13） for geometrical method）. Furthermore, the correlation between the two mathematical models appeared to be low （r = 0. 15）. Although OBT is simple and safe, its correlation with scintigraphy appears to be weak. The usefulness of this test for measuring gastric emptying thus requires further validation.

关 键 词：^13C-辛酸呼气试验 胃排空时间 闪烁显像 非线性最小二乘法 测定 功能性消化不良 数学模型 OBT 

分 类 号：R573.9[医药卫生—消化系统]