实验性兔角膜新生血管的防治研究  

A Preventive and Therapeutic Study of Experimental Corneal Neovascularization

作　　者：赵长松[1] 张泺[1] 沈远萍[1] 

机构地区：[1]武汉同济医科大学附属同济医院眼科

出　　处：《同济医科大学学报》1996年第5期399-401,共3页Acta Universitatis Medicinae Tongji

摘　　要：为研究角膜新生血管的防治疗法，用角膜缝线方法，诱导１２只家兔２４只眼角膜新生血管形成。缝线后的第３ｄ，１２只家兔随机分为３组，将不同药物分别注射于结膜下，观察每眼角膜新生血管生长情况。结果：平阳霉素（０．５ｍｇ）组新生血管的长度（ｘ±ｓｘ）为（２．８９±０．０３）ｍｍ，较对照组（４．８９±０．０２）ｍｍ短，但差异无显著意义（Ｐ＞０．０５）；肝素（２５００Ｕ）加可的松（１２．５ｍｇ）组新生血管的长度为（２．０４±０．０４）ｍｍ，明显短于对照组，差异有非常显著意义（Ｐ＜０．０１）。结果表明，肝素加可的松混合液结膜下注射防治兔角膜新生血管的作用优于平阳霉素。In order to study the preventive and therapeutic methods for corneal Neovascularization,we used suturation on cornea to induce the vascularization in twenty-four eyes of twelve rabbits. On the third day after suturation the twelve rabbits were divided into three groups:the contrast group(the first group),the group treated with bleomycin(0.5mg,0.5 ml)(the second group)and the group with subconjunctival injection of heparin(2 500U,0.2 ml) combined with cortison (12.5mg,0.5 ml) (the third group).The growth of neogenetic vessels of each eye was carefully observed. We found that the vascularization in the second group (length average 2.89 mm) was slighter than that of the contrast group (4.89mm)(P>0.05) and the vascularization in the third group (2.04 mm) was significantly slighter than that of the contrast group (P<0.01). The results show that the effect of subconjuctival injection of heparin combined with cortisone into experimental rabbits to prevent vascularization of cornea is better than that of bleomycin.

关 键 词：角膜疾病 新生血管 平阳霉素 肝素 可的松 

分 类 号：R772.205[医药卫生—眼科] R988.1[医药卫生—临床医学]