紫杉醇联合氟尿嘧啶和顺铂方案治疗晚期胃癌  

Paclitaxel Combined with 5-Fluorouracil and Cisplatin in the Treatment of Advanced Gastric Cancer

作　　者：高建峰[1] 王文辉[1] 李永青[1] 

机构地区：[1]潍坊医学院附属潍坊市人民医院肿瘤内科,山东潍坊261041

出　　处：《潍坊医学院学报》2006年第5期343-344,共2页Acta Academiae Medicinae Weifang

摘　　要：目的 观察紫杉醇联合氟尿嘧啶及顺铂（PFC）方案治疗1晚期胃癌的临床疗效和毒副反应。方法 晚期胃癌患者20例，给予紫杉醇（PTX）65mg／m^2，静滴4h，第1，8天给药；氟尿嘧啶（5-FU）500mg／m^2，静滴6h，第1～5天；顺铂（CDDP）20mg／m^2，静滴，第1～5天，21d为1周期，至少2个周期后评价疗效和毒副反应。结果 全组20例均可评价疗效，获得CR2例，PR10例，SD5例，PD3例，近期客观有效率60．0％，中位TTP为7．5个月。主要毒副反应为骨髓抑制、恶心呕吐和脱发。结论 PFC方案治疗晚期胃癌疗效较高，毒副反应轻，多数患者耐受良好，值得临床推广运用。Objective To evaluate the efficacy and toxicity of paclitaxel combined with 5-fluorouraeil and eisplatin （ PFC ） regimen in patients with advanced gastric cancer. Methods Twenty cases with advanced gastric cancer were enrolled . PTX 65mg/m^2 iv 4h d1,8 ; 5-FU 500mg/m^2 iv 6h d1 - d5 and CDDP 20mg/m^2 iv d1 - d5 ;and repeated every 21days. Results All 20 cases were available for objective response. CR 2 cases, PR 10 cases, SD 5 cases, PD 3 cases. The overall response rates（ORR） and median TTP was 60.0% and 7.5 months respectively. The main toxicities were bone marrow suppression, nausea/vomiting and alopecia. Conclusion PFC regimen is a high response regimen tor advanced gastric cancer with well-tolerated toxicity,which can be practiced safely.

关 键 词：胃肿瘤晚期 紫杉醇 氟尿嘧啶 顺铂 化疗 

分 类 号：R735.2[医药卫生—肿瘤]