DC-SIGN and Immunoregulation  

作　　者：Tong Zhou Yongxi Chen Li Hao Yanyun Zhang 

机构地区：[1]Department of Nephrology, Ruijin Hospital Affiliated to Shanghai Jiaotong University, School of Medicine, Shanghai 200025, China [2]Shanghai Institute of Immunology and Institute of Health Sciences, Shanghai Institute of Biological Sciences, Shanghai Jiao Tong University, Shanghai 200025, China

出　　处：《Cellular & Molecular Immunology》2006年第4期279-283,共5页中国免疫学杂志（英文版）

基　　金：supported by National Natural Science Foundation of China(No.39970340,No.30570865);Natural Science Foundation of Shanghai(No.02ZB14041,No.034119916).

摘　　要：Dendritic cells （DCs） are known to be the most powerful professional antigen-presenting cells so far. It could activate primary immune response, and also downregulate immune response. DCs have a unique character of immunoregulation. DC-SIGN, a molecule designated as CD209, is one member of the C-type lectin superfamily. It is not only a pattern recognition receptor but implicated in immunoregulation of DCs. DC-SIGN has become hotspot of recent studies because of its important role in mediating DC adhesion, migration, inflammation, activating primary T cell, triggering immune response and participating in immune escape of pathogens and tumors. These studies on DC-SIGN involved in primary and secondary immune response and relevant mechanism will certainly provide us with a new method in treating and preventing certain diseases.Dendritic cells （DCs） are known to be the most powerful professional antigen-presenting cells so far. It could activate primary immune response, and also downregulate immune response. DCs have a unique character of immunoregulation. DC-SIGN, a molecule designated as CD209, is one member of the C-type lectin superfamily. It is not only a pattern recognition receptor but implicated in immunoregulation of DCs. DC-SIGN has become hotspot of recent studies because of its important role in mediating DC adhesion, migration, inflammation, activating primary T cell, triggering immune response and participating in immune escape of pathogens and tumors. These studies on DC-SIGN involved in primary and secondary immune response and relevant mechanism will certainly provide us with a new method in treating and preventing certain diseases.

关 键 词：DC DC-SIGN pattern recognition receptor IMMUNOREGULATION 

分 类 号：R392[医药卫生—免疫学]