细胞分化抑制子Id1在前列腺癌中的表达及意义  

Expression and significance of Id1 in prostate cancer

作　　者：徐晓慧[1] 于小玲[1] 韩保健[2] 徐文华[3] 刘志芳[4] 周荣祥[2] 

机构地区：[1]青岛大学医学病理生理学教研室,山东青岛266021 [2]青岛大学医学院附属市立医院泌尿外科,山东青岛266000 [3]青岛大学医学院生物化学教研室,山东青岛266021 [4]莱州市人民医院病理科,山东烟台261400

出　　处：《现代肿瘤医学》2006年第10期1235-1237,共3页Journal of Modern Oncology

基　　金：青岛市科技局资助项目(No.05-1-NS-76;04-2-JZ-93)

摘　　要：目的:细胞分化抑制子Id1(inhibitor of differentiation or inhibitor of DNA binding)蛋白与肿瘤的发生、侵袭及远处转移有关。本研究主要观测人前列腺癌组织中Id1蛋白的表达,并分析其应用价值。方法:采用免疫组化SP法检测43例前列腺癌(prostate cancer,PC)、12例前列腺增生(benign prostatic hyperplasia,BPH)和2例正常前列腺组织中Id1蛋白的表达。结果:Id1蛋白在正常前列腺组织中无表达;BPH组织中无或弱表达(5/12);所有前列腺癌组织都有阳性表达(43/43),而且大多数以中、高度表达为主(与BPH相比,P<0.01);前列腺癌中Id1的表达水平与Gleason分级成正比(rs=0.63P<0.01)。结论:人前列腺癌组织中,Id1蛋白有过度表达,且与前列腺癌的Gleason分级呈正相关,表明与癌组织的恶性程度有关。Id1蛋白有可能作为判断前列腺癌发展的一种新的肿瘤标志。Objective：It has been proved recently that Id1 （inhibitor of differentiation or inhibitor of DNA binding） is reiated to tumorigenesis, invasion and metastasis in some cancers. This study was to explore the expression of Id1 protein in human prostate cancer, and to analysze its potential clinical significance. Methods： By SP immunohistochemistry, the expression of Id1 protein were detected in paraffin -embeded specimens of 43 prostate cancer （PC） cases, 12 benign prostatic hyperplasia （BPH） cases and 2 normal prostate. Results：There were no Id1 expression in normal prostate tissue, and negative to weak expression of Id1 in BPH（5/12）. In contrast, all of prostate cancer （43/43） tissues showed moderate to high positive Id1 expression, which was significantly higher than that of BPH （ P 〈 0.01 ） . Furthermore, Id1 overexpression was correlated with the increasing of Gleason grade （ P 〈 0.01 ）. Conclusion： In prostate cancer, Id1 protein is overexpressed and the level of Id1 expressed is positive correlated with Gleason grade, suggesting that Id1 is associated with prostate tumor malignancy. Id1 might be used as a new marker of PC for diagnosis and therapy.

关 键 词：Id1蛋白 前列腺癌 免疫组化法 

分 类 号：R737.25[医药卫生—肿瘤]