DNA损伤修复基因hOGG1的遗传多态与乙肝相关性HCC的风险  

Impact of DMA repair gene hOGG1 Ser326Cys polymorphism on the risk of hepatocellular carcinoma

作　　者：张昊[1] 郝冰涛[2] 贺福初[2] 

机构地区：[1]河南省人民医院老年病研究中心,河南省郑州市450003 [2]军事医学科学院放射医学研究所,北京市100850

出　　处：《世界华人消化杂志》2006年第23期2311-2314,共4页World Chinese Journal of Digestology

基　　金：国家863高技术发展项目;No.2001AA224011~~

摘　　要：目的:探讨DNA损伤修复基因hOGGI的遗传多态Ser326Cys与肝细胞癌(HCC)易感性的关系．方法:应用基因测序分型方法,分析96例HCC患者和96例健康对照hOGG1的遗传多态及与HBV感染的交互作用．结果:HCC病例组的Cys／Cys,Cys／Ser和Ser／Ser基因型分别为20．9％,44．2％和34．9％．Ser／Cys杂合子个体的OR值为1．5,Cys／Cys纯合子个体的OR值为1．9,明显高于Ser/Ser个体,表现出剂量效应．HBV感染者发生HCC的相对风险度是非HBV感染者的9倍(OR=9．2;95％CI 0．99-5．9)．对于HCC,hOGG1-Ser326Cys变异或HBV感染单一因素的OR值分别为5．5 (95％CI 0．7-240．1)和10．9(95％CI1．6-453．3),但携带变异基因者如果感染HB V,OR值则高达27．8(95％CI4．7-970．2)．结论:DNA修复基因hOGG1的Cys等位基因可能增加HCC的遗传易感性,他与HBV协同在乙肝相关性HCC的发生中起着重要作用．AIM：To investigate the associations of susceptibility to hepatocellular carcinoma （HCC） with DNA repair gene hOGG1 Ser326Cys polymorphism. METHODS： The polymorphism of Ser326Cys in DNA damage repair gene hOGG1 was analyzed by sequencing and genotyping in 96 HCC patients and healthy controls. RESULTS： The frequencies of Cys/Cys, Cys/Ser and Ser/Ser genotypes were 20.9%, 44.2% and 34.9%, respectively. The odd ratio （OR） of heterozygote Ser/Cys was 1.5, and that of homozyosity Cys/Cys was 1.9, which was significantly higher that of Ser/Ser, respectively. The relative risk of HCC in patients with hepatitis B virus （HBV） infection was over 9 times in patients without HBV infection （OR = 9.2; 95%CI 0.99-5.9）. Furthermore, the OR for the variant genotype and HBV infection was 5.5 （95%CI 0.7-240.1） and 10.9 （95%CI1.6-453.3）, respectively, while that was 27.8 （95%CI4.7-970.2） in patients with both variant genotype and HBV infection. CONCLUSION： The allele Cys for hOGG1 gene may increase the genetic susceptibility of HCC, in which HBV infection plays a synergic role.

关 键 词：肝细胞肝癌 DNA修复基因 遗传多态 HBV感染 

分 类 号：R735.7[医药卫生—肿瘤]