乳腺癌中白细胞介素-10和血管内皮生长因子的表达及其对树突状细胞的抑制作用  

Expressions of interleukin-10 and vascular endothelial growth factor in breast carcinoma and their inhibition to dendritic cells

作　　者：王健[1] 马鸿达[2] 孙燕[3] 谷彦军[4] 曹群[2] 古强[2] 

机构地区：[1]天津医科大学肿瘤医院肝胆外科,300060 [2]天津医科大学病理学教研室 [3]天津医科大学肿瘤医院病理科 [4]天津武警医学院病理学教研室

出　　处：《中华实验外科杂志》2006年第10期1184-1185,i0002,共3页Chinese Journal of Experimental Surgery

摘　　要：目的探讨乳腺癌中白细胞介素(IL)-10和血管内皮生长因子(VEGF)的表达及其对树突状细胞(DC)的影响。方法应用免疫组织化学方法检测71例乳腺浸润性导管癌中IL-10和VEGF的表达及S100+DC和CD1a+DC的分布情况,分析它们之间的关系。结果IL-10和VEGF的阳性率分别为69．0%(49/71)和70．4%(50/71)。S100+DC和CD1a+DC的阳性率分别为76．1%(54/71)和53 5%(38/71)。IL-10表达仅与CD1a+DC的密度呈负相关(r_s=-0．244,P＜0．05),而VEGF表达与S100+DC和CD1a+DC的密度均呈负相关(分别r_s=-0,380,P＜0．01和r_s=-0．476,P＜0．01)。结论乳腺癌细胞分泌的IL-10和VEGF可能通过抑制DC的产生和分化成熟而抑制机体对肿瘤细胞的免疫杀伤作用。Objective To explore the expression of IL-10 and VEGF and their influence on dentritic cells （DCs） in breast carcinoma. Methods The expression of IL-10 and VEGF and the distribution of S100 ＋ DC and CDla ＋ DC in 71 cases of breast infiltrating ductal carcinoma were examined by immunohistochemistry and their relations were analyzed. Results The positive rates of IL-10 and VEGF were 69.0 % （ 49/71 ） and 70.4 % （ 50/71 ） respectively. The positive rates of S100 ＋ DC and CD1a ＋ DC were 76.1% （54/71） and 53.5% （38/71） respectively. The expression of IL-10 was only negatively correlated with CDla ＋ DC （ rs = - 0. 244, P 〈 0.05 ）, while the expression of VEGF was both negatively correlated with S100 ＋ DC and CDla ＋ DC （ rs = - 0. 380, P 〈 0.01 and rs= = - 0. 476, P〈 0.01 respectively）. Conclusion IL-10 and VEGF secreted by breast cancer cells may inhibit the immune killing function of patients through suppressing the development and mature of DCs.

关 键 词：乳腺癌 白细胞介素-10 血管内皮生长因子 树突状细胞 

分 类 号：R737.9[医药卫生—肿瘤]