健脾补肾法治疗精神分裂症患者注意损害的效果评估  

Attention impairment in patients with schizophrenia after the treatment of strengthening the spleen and invigorating the kidney

作　　者：唐永怡[1] 贾竑晓[1] 周方[1] 曹欣冬[1] 袁海宁[1] 张继志[1] 

机构地区：[1]首都医科大学附属北京安定医院二科,北京市100088

出　　处：《中国临床康复》2006年第39期10-12,共3页Chinese Journal of Clinical Rehabilitation

基　　金：北京市中医科技发展基金资助项目(97-02)~~

摘　　要：目的:观察健脾补肾法治疗精神分裂症注意损害的疗效。方法:精神分裂症患者均为1998-05/1999-09北京安定医院的住院患者60例。①配对后随机分为中药治疗组和安慰剂组。另选30例正常人为正常对照组。中药治疗组患者服用氯丙嗪的同时服用健脾补肾合剂(为院内制剂,主要成分为:党参、茯苓、白术、生地、菟丝子、柴胡、丹皮等)。2次/d,125mL/次。氯丙嗪用量为300～450mg。疗程为8周。安慰剂组患者服用氯丙嗪的同时服用由焦糖为辅料制成色泽与健脾补肾合剂一样的合剂作为安慰剂。服法为2次/d,125mL/次。氯丙嗪用量同中药治疗组。正常对照组不用任何治疗方法。②中药治疗组被试和安慰剂组被试分别在入组前和研究结束时进行注意测查和阴性阳性症状量表(PANSS)评分(分值越高表示症状越重),正常对照组被试在入组时做注意测查。结果:①各组各项注意力活动指标变化:反应时间分测验和X分测验中的平均反应时间和漏答数中药治疗组、安慰剂组与正常对照组相比有明显差异(P<0.01);中药治疗组治疗后漏答数明显少于治疗前,平均反应时间明显短于治疗前;治疗后中药治疗组漏答数明显少于安慰剂组(反应时间分测验:4.36±1.04,6.47±0.61,P<0.05;X分测验:5.68±0.37,7.47±0.52,P<0.05),平均反应时间明显短于安慰剂组[反应时间分测验(393±137),(478±162)ms;P<0.05;X分测验:(447±183),(515±1.83)ms,P<0.05]。②中药治疗组安慰剂组阳性和阴性症状量表分比较:阳性症状量表分中药治疗组、安慰剂组治疗后评分均明显低于治疗前(23.23±2.57比51.23±2.23;24.21±2.18比50.18±1.78,P均<0.05);阴性症状量表分只有中药治疗组治疗后评分明显低于治疗前(11.18±1.89,20.18±1.57,P<0.05),而对照组治疗前后差异无显著性(P>0.05)。结论:健脾补肾法对精神分裂症注意损害和和阴性症状有改善作用。AIM： To investigate the effects on patients with attention impairment of schizophrenia by strengthening the spleen and invigorating the kidney. METHODS： Sixty inpatients with schizophrenia between May 1998 and September 1999 were selected from Beijing Anding Hospital. ① Patients were randomly divided into traditional Chinese medicine treatment group （TCM treatment group） and placebo group. Another 30 healthy adults were selected as the normal control group. Patients in the TCM treatment group were treated with chlorpromazine as well as herb mixture which can strengthen the spleen and invigorate the kidney （manufactured by the Hospital with the main components of Radix Codonopsis, Poria, Rhizoma Atractylodis Macrocephalae, Radix Rehmanniae, Semen Cuscutae, Radix Bupleuri and cortex moutan etc.） twice a day and 125 mL each time. The dose of chlorpromazine was 300-450 mg, and the course of treatment was 8 weeks. Patients in the placebo group were treated by taking chlorpromazine and the mixture of caramel based mixture, which was in the same color of Jianpi Bushen composition simultaneously with 125 mL per time and twice a day, and the dose of chlorpromazine in the placebo group was the same as that in the TCM treatment group. Patients in the normal control group received no treatment. ② Patients in the TCM treatment group and placebo group were evaluated by PANNS （higher score indicated severer symptoms） respectively before grouping and ＇after the investigation, while subjects in the normal control group were tested while grouping. RESULTS： ①Changes in indexes of attention activity： In reaction time task and X test, the omission rate and mean reaction time were significantly different among TCM treatment group, placebo group and normal control group （P 〈0.01）, while the omission rate in the TCM treatment group after treatment was obviously less than that before treatment, and the mean reaction time was remarkably shortened than that before the treatment. The omission rate after the

关 键 词：精神分裂症 注意缺陷和分裂性行为障碍/中医药疗法 健脾 补肾 

分 类 号：R749.3[医药卫生—神经病学与精神病学]