乳腺癌组织微阵列HER-2和COX-2的表达及其相关性研究  

Analysis of HER-2,COX-2 expression and their relationship in human breast cancer: high throughput tissue microarray analysis

作　　者：刘风军[1] 鹿伟[1] 孙德刚[1] 成玉霞[1] 孙青[1] 

机构地区：[1]山东省千佛山医院病理科,山东济南250014

出　　处：《中华肿瘤防治杂志》2006年第17期1317-1320,共4页Chinese Journal of Cancer Prevention and Treatment

基　　金：山东省科技发展计划项目(2002BB1BCB4)

摘　　要：目的:探讨HER-2和COX-2在乳腺癌组织中的表达及其意义。方法:构建乳腺癌组织微阵列,应用免疫组织化学SP法检测160例乳腺浸润性导管癌患者HER-2和COX-2的表达。结果:乳腺癌组织中HER-2和COX-2的阳性表达率分别为35%(56/160)和55·6%(89/160),且HER-2和COX-2的表达均与组织学分级、淋巴结转移、雌激素受体、孕激素受体及无病生存期显著相关,P<0·05或P<0·01;COX-2与HER-2的表达密切相关,P<0·01。结论:HER-2和COX-2的表达与乳腺癌的生物学行为有关,同时检测HER-2和COX-2可能对乳腺癌预后的判断及靶向治疗的选择提供帮助。OBJECTIVE： To investigate HER-2, COX-2 expressions and evaluate their significance, in human breast cancer. METHODS： HER-2 and COX-2 expressions were detected in 160 samples of breast invasive ductal carcinomas with the immunohistochemically performing tissue microarray （TMA） technology. RESULTS： HER-2 and COX-2 was overexpressed in 55.6% （89/160） and 35%（56/160） separately of breast carcinomas. Increased HER-2 and COX-2 expressions corresponded to histological grading, lymph node metastasis, ER state and PR state （P〈0. 05 or P〈0.01）, and disease-free survival, P〈0. 01. A significant association between HER-2 and COX-2 expressions was observed, P〈0. 01. CONCLUSIONS： Both HER-2 and COX-2 expressions are significantly associated with the biological behavior of human breast cancer, and might therefore be useful prognostic indicators as well as targets for therapy.

关 键 词：乳腺肿瘤 HER-2 COX-2 组织微阵列 免疫组织化学 

分 类 号：R737.9[医药卫生—肿瘤]