Her-2/neu,Syndecan-1在胃癌中的表达及意义  

Effect of Her-2/neu and syndecan-1 in gastric carcinoma

作　　者：王潍博[1] 刘丰基[2] 崔言刚[1] 

机构地区：[1]山东省立医院化疗科,山东济南250021 [2]潍坊市人民医院保健科,山东潍坊261041

出　　处：《山东大学学报（医学版）》2006年第9期914-917,共4页Journal of Shandong University:Health Sciences

摘　　要：目的:检测胃癌组织中Her-2/neu,Syndecan-1表达情况,探讨二者在胃癌发生发展及侵袭、转移中的作用。方法:应用免疫组化SP法检测112例胃癌组织及40例正常胃粘膜中Her-2/neu,Syndecan-1表达。结果:①112例胃癌组织和40例正常胃粘膜中Her-2/neu阳性表达率分别为20.5%和5%,Syndecan-1阳性表达率分别为46.4%和100.0%。胃癌组织Her-2/neu阳性表达率显著高于正常胃粘膜阳性表达率(χ2=5.17,P<0.05),正常胃粘膜Syndecan-1阳性表达率显著高于胃癌组织(χ2=20.80,P<0.01);②胃癌组织Her-2/neu的表达与胃癌分化程度(χ2=4.82,P<0.05),TNM分期(χ2=5.37,P<0.05)、淋巴结转移多少(χ2=6.42,P<0.05)及浆膜浸润(χ2=7.30,P<0.01)均显著相关;③胃癌组织Syndecan-1的表达与胃癌分化程度、淋巴结转移呈负相关(χ2=11.83,P<0.01和χ2=13.74,P<0.01);④胃癌组织中Her-2/neu阳性表达与Syndecan-1的阴性表达显著相关(χ2=14.25,P<0.01)。结论:①Her-2/neu高表达显示胃癌恶性程度高、分期晚、预后不良;②Syndecan-1属保护性因素,在恶性程度高、分期晚的患者中表达降低;③Her-2/neu阳性表达的胃癌组织中Syndecan-1的表达降低。Objective： To study the effect of Her-2/neu and Syndecan-1 in gastric carcinoma. Methods： The expressions of Her-2/neu and Syndecan-1 were measured by using immunohistochemistry method in 112 patients with gastric cancer and 40 healthy controls. Results： ① Her-2/neu was expressed in 20.5 % of the gastric cancer tissue and 5.0% of the healthy gastric mucosa （ X^2 = 5.17, P 〈 0.05）, and Syndecan-1 was expressed in 46.4% of the gastric cancer tissue and 100% of the healthy mucosa （ X^2 = 20.80, P 〈 0.01 ） ; ② the expression of Her-2/neu was significantly correlated with the differentiation, lymph node metastasis and clinical stage （ P 〈 0.05） and depth of invasion （P 〈0.01）; ③ the expression of Syndecan-1 was significantly correlated with the differentiation and the lymph node metastasis （P 〈 0.01）. Conclusion： ① The expression of Her-2/neu is significantly correlated with the clinicopathological factors （ P 〈 0.05） which suggests that Her-2/neu is a risk factor for gastric cancer; ② the expression of Syndecan- 1 is significantly correlated with the differentiation and the lymph node metastasis, which suggests that Syndecan-1 is a protective factor for gastric cancer; ③ the expression of Her-2/neu in gastric cancer tissue is significantly correlated with that of Syndecan-1.

关 键 词：胃肿瘤 HER-2/NEU SYNDECAN-1 免疫组织化学 肿瘤分化 肿瘤转移 预后 

分 类 号：R735.2[医药卫生—肿瘤]