DNA修复基因XRCC1和XPC多态性与胰腺癌风险关联研究  

Polymorphisms of the DNA repair genes XRCC1 and XPC: relationship to pancreatic cancer risk

作　　者：王丽[1] 林东昕[2] 陆星华[3] 缪小平[2] 李辉[1] 

机构地区：[1]中国医学科学院基础医学研究所中国协和医科大学基础医学院流行病学教研室,北京100005 [2]中国协和医科大学肿瘤研究所病因与癌变研究室 [3]北京协和医院消化内科

出　　处：《卫生研究》2006年第5期534-536,共3页Journal of Hygiene Research

基　　金：卫生部临床重点学科资助项目(No.20010102)

摘　　要：目的探讨碱基切除修复相关基因XRCC1及核酸切除修复基因XPC基因多态与胰腺癌发病风险的关系。方法采用病例一对照研究（胰腺癌新发病例101人，对照337人）方法，分析XRCC1 Arg399Gln、Arg194Trp及XPC第9内含子的AT双核苷酸的插入／缺失（PAT）多态与胰腺癌风险的关系。结果经年龄、性别及吸烟、饮酒状态调整后，携带XRCC1 399Arg／Gln及Gin／Gin基因型的个体较399Arg／Arg者发生胰腺癌的风险有所降低，OR值分别为0．83（95％CI，0．52～1．34，P=0．41）和0．64（95％CI，0．21～1．66，P=0．30），但没有达到统计学显著水平。携带PAT＋／＋基因型者发生胰腺癌的风险为XPC／PAT-／-基因型者的0．30倍（95％CI，0．10—0．76，P=0．02）。结论XPC—PAT多态可能在胰腺癌的发生中起着一定的作用。Objective To determine whether genetic polymorphisms in XRCC1 and XPC are associated with risk of pancreatic cancer. Methods A case-control study was conducted in 101 incident cases with pancreatic cancer and 337 controls （matched for age, sex and ethnicity） to investigate whether genetic polymorphisms in DNA repair genes XRCC1 （Arg194Trp and Arg399Gln） and XPC （an intronic biallelic poly （AT） insertion/deletion polymorphism, XPC-PAT） were associated with risk of pancreatic cancer. The odds ratios （ORs） and their 95 % confidence intervals （CIs） were calculated by unconditional logistic regression models and adjusted for potential confounding factors. Results There was a small, non-significant decrease in risk for pancreatic cancer in those carrying Gin/Gin genotype at XRCC1 Arg399Gln site （OR 0.64, 95% CI 0.21 - 1.66, P = 0.30） compared with those having Arg/Arg genotypes. And the XRCC1 Arg194Trp polymorphism was not significantly associated with risk of pancreatic cancer. For XPC-PAT polymorphism, 5.0% of cases and 13.4% of controls were homozygous for the variant allele （PAT＋ / ＋ ）, resulting in an OR of 0.30 （95% CI 0. 10 - 0.76, P = 0.02）, which suggested that the PAT ＋/＋ genotype might have protective effect against pancreatic carcinogenesis. Conclusions This study suggest that XPC-PAT polymorphisms may contribute to the risk of pancreatic cancer in our study population.

关 键 词：胰腺癌 XRCC1 XPC 基因多态 易感性 

分 类 号：R735.9[医药卫生—肿瘤] Q789[医药卫生—临床医学]