对羟基苯甲酸酯类物质的雌激素活性  

Estogenic activities of parabens

作　　者：葛均辉[1] 常兵[1] 

机构地区：[1]中国疾病预防控制中心职业卫生与中毒控制所,北京100050

出　　处：《卫生研究》2006年第5期650-652,共3页Journal of Hygiene Research

基　　金：国家自然科学基金资助项目(No.30150003);国家科技部社会公益研究项目(No.2001DIB0059)

摘　　要：对羟基苯甲酸酯类物质广泛用做食品、药品、化妆品防腐剂,近年国外的研究表明,对羟基苯甲酸酯类物质引起雌性大、小鼠子宫重量增加,影响雄性动物睾丸晚期精子发生,降低仔鼠活产比例与体重,使雄性仔鼠附睾精子数、精子活动度降低。对羟基苯甲酸酯类物质能抑制[3H]17β-雌二醇([3H]E2)与雌激素受体(ER)的结合,并引起两种雌激素依赖细胞株MCF-7和ZR-75-1的增殖,增加MCF-7细胞转染(ERE-CAT受体基因)和内源性(pS2)基因的表达,显示该类物质有弱雌激素活性。Objective Studies indicated that parabens, used as anti-microbial agents in food, cosmetics, and pharmaceuticals, produced a positive uterotrophic response in vivo. They also damaged the late stages of spermatogenesis, altered proportion of pups born alive, and body weight of offspring. They reduced the number of sperm in the epididymis, and the sperm motile activity in male offspring. Parabens could compete with [^3 H] 17β-estradiol for binding to the estrogen receptor. The proliferation of two estrogen-dependent cell lines MCF-7 and ZR-75-1 could be increased by parabens. They also increased expression of both transfected and endogenous estrogen-regulated genes in MCF-7 cells. The studies demonstrated parabens were weakly estrogenic.

关 键 词：对羟基苯甲酸类 雌激素活性 内分泌干扰物 

分 类 号：TS202.3[轻工技术与工程—食品科学] TS201.6[轻工技术与工程—食品科学与工程]